I Ugrinova, E Pasheva. (2016) HMGB1 Protein: A Therapeutic Target Inside and Outside the Cell, Advances in Protein Chemistry and Structural Biology 2016

S Yusein-Myashkova, I Stoykov, A Gospodinov, I Ugrinova, E Pasheva. (2016) The repair capacity of lung cancer cell lines A549 and H1299 depends on HMGB1 expression level and the p53 status, Journal of biochemistry

S Yusein-Myashkova, I Ugrinova, E Pasheva. (2016) Non-histone protein HMGB1 inhibits the repair of damaged DNA by cisplatin in NIH-3T3 murine fibroblasts, BMB Rep 49 (2), 99-104



Patel A, Lee HO, Jawerth L, Maharana S, Jahnel M, Hein MY, Stoynov S, Mahamid J, Saha S, Franzmann TM, Pozniakovski A, Poser I, Maghelli N, Royer LA, Weigert M, Myers EW, Grill S, Drechsel D, Hyman AA, Alberti S.(2015) A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation, Cell. 2015 Aug 27;162(5):1066-77

X Gaume, AM Tassin, I Ugrinova, F Mongelard, K Monier, P Bouvet. (2015) Centrosomal nucleolin is required for microtubule network organization, Cell Cycle 14 (6), 902-919


S Yusein-Myashkova, I Ugrinova, E Pasheva. (2015) Interdependence of expression level of high mobility group box protein 1 and tumour suppressor protein p53, Comptes rendus de lÁcademie bulgare des Sciences 68 (12), 1541-1546 2015

Todorova, J., E. Pasheva. (2015) The synthesis of recombinant HMGB1 protein in E.coli is modulated by its C-terminus domain. Comptes rendus de lÁcademie bulgare des Sciences, 68

V Uzunova, A Georgieva, S Apostolova, I Ugrinova, R Toshkova. (2015) Combined treatment of cancer cells with the new anti-neoplastic agents erufosine and doxorubicin, International journal of molecular medicine 36, S54-S54


Uzunova SD, Zarkov AS, Ivanova AM, Stoynov SS, Nedelcheva-Veleva MN.(2014) The subunits of the S-phase checkpoint complex Mrc1/Tof1/Csm3: dynamics and interdependence, Cell Div. 2014 Oct 31;9:4.

I Slavchev, GM Dobrikov, V Valcheva, I Ugrinova, E Pasheva, V Dimitrov. (2014) Antimycobacterial activity generated by the amide coupling of (−)-fenchone derived aminoalcohol with cinnamic acids and analogues, Bioorganic & medicinal chemistry letters 24 (21), 5030-5033  


Zarkov A, Stoynov S, Nedelcheva-Veleva M. (2014) Novel glass slide preparation system for single DNA molecules analysis, Biotechnol Biotechnol Equip. 2014 Jan 2;28(1):112-117.


GM Dobrikov, V Valcheva, Y Nikolova, I Ugrinova, E Pasheva, V Dimitrov. (2014) Enantiopure antituberculosis candidates synthesized from (−)-fenchone, European journal of medicinal chemistry 77, 243-247 


Georgi M. Dobrikov , Violeta Valcheva, Yana Nikolova, Iva Ugrinova, Evdokia Pasheva, Vladimir  Dimitrov. (2013) Efficient synthesis of new (R)-2-amino-1-butanol derived ureas, thioureas and acylthioureas and in vitro evaluation of their antimycobacterial activity, European Journal of Medicinal Chemistry,http://dx.doi.org/10.1016/j.ejmech.2013.02.034

Zarkov A, Vasilev A, Deligeorgiev T, Stoynov S, Nedelcheva-Veleva M.(2013) Novel fluorescent dyes for single DNA molecule techniques.,Mol Imaging., 1;12(2):90-9

Nedelcheva-Veleva MN, Sarov M, Yanakiev I, Mihailovska E, Ivanov MP, Panova GC, Stoynov SS. (2013) The thermodynamic patterns of eukaryotic genes suggest a mechanism for intron-exon recognition, Nat Commun. 2013;4:2101

Osmanov T, Ugrinova I, Pasheva E.(2013) The chaperone like function of the nonhistone protein HMGB1., Biochem Biophys Res Commun, 8;432(2):231-5


Todorova J, Pasheva E.(2012), High mobility group B1 protein interacts with its receptor RAGE in tumor cells but not in normal tissues. Oncol Lett, 3(1):214-218.

Cong R, Das S, Ugrinova I, Kumar S, Mongelard F, Wong J, Bouvet P.(2012), Interaction of nucleolin with ribosomal RNA genes and its role in RNA polymerase I transcription. Nucleic Acids Res, 40(19):9441-54. 1.

Ugrinova I, Zlateva S, Pasheva E.(2012), The effect of PKC phosphorylation on the "architectural" properties of HMGB1 protein. Mol Biol Rep.,  39(11):9947-53.


Ugrinova I, Pashev IG, Pasheva EA. (2011), Cyclin-dependent kinase 5 phosphorylates mammalian HMGB1 protein only if acetylated. J Biochem. May;149(5):563-8.

Elenkov I, Pelovsky P, Ugrinova I, Takahashi M, Pasheva E., (2011) The DNA binding and bending activities of truncated tail-less HMGB1 protein are differentially affected by Lys-2 and Lys-81 residues and their acetylation.Int J Biol Sci.; 7(6):691-9.

Older publications

Momekov G, Karaivanova M, Ugrinova I, Pasheva E, Gencheva G, Tsekova D, Arpadjan S, Bontchev PR. (2010),  In vitro pharmacological study of monomeric platinum(III) hematoporphyrin IX complexes.Invest New Drugs.

Kostova N, Zlateva S, Ugrinova I, Pasheva E. (2010), The expression of HMGB1 protein and its receptor RAGE in human malignant tumors. Mol Cell Biochem., 337 :251-8.

Momekov GTs, Ugrinova I, Pasheva EA, Bakalova AG, Varbanov HP, Ferdinandov DV, Ivanov DS, Konstantinov SM. (2009), In vitro biochemical and pharmacological evaluation of a novel cytotoxic dinuclear platinum(II) complex with 3-amino-5-methyl-5-phenylhydantoin. Ann N Y Acad Sci., 1171:649-58.

Ugrinova I, Pashev IG, Pasheva EA. (2009), Nucleosome binding properties and Co-remodeling activities of native and in vivo acetylated HMGB-1 and HMGB-2 proteins. Biochemistry, 48: 6502-7.

Ugrinova I, Zlateva S, Pashev IG, Pasheva EA. (2009), Native HMGB1 protein inhibits repair of cisplatin-damaged nucleosomes in vitro. Int J Biochem Cell Biol., 41:1556-62.

Pelovsky P, Pashev IG, Pasheva E. (2009), Interplay between in vitro acetylation and phosphorylation of tailless HMGB1 protein. Biochem Biophys Res Commun. 380:138-42.

Ugrinova I, Pashev IG, Pasheva EA. (2009), Post-synthetic acetylation of HMGB1 protein modulates its interactions with supercoiled DNA.Mol Biol Rep.,36:1399-404.

Kostova N, Zlateva S, Pasheva E. (2009), IMMUNOCHISTOCHEMICAL DETERMINATION OF HMGB1 PROTEIN LEVEL IN HUMAN MALIGNANT TUMOURS. Comptes rendus de l"Academie Bulgare des Sciences, 62:229-232.

Topalova D, Ugrinova I, Pashev IG, Pasheva EA. (2008), HMGB1 protein inhibits DNA replication in vitro: a role of the acetylation and the acidic tail.Int J Biochem Cell Biol., 40:1536-42.

Pelovsky P, Pasheva E. (2008), MUTAGENESIS AT THE SITES OF POSTSYNTHETIC ACETYLATION OF THE NON-HISTONE PROTEIN HMGB-1 AND ITS TRUNCATED FORM. Comptes rendus de l"Academie Bulgare des Sciences, 61:1151-1158.  

Ugrinova I, Mitkova E, Moskalenko C, Pashev I, Pasheva E. (2007), DNA bending versus DNA end joining activity of HMGB1 protein is modulated in vitro by acetylation. Biochemistry,46:2111-7.

Kraeva RI, Krastev DB, Roguev A, Ivanova A, Nedelcheva-Veleva MN, Stoynov SS. (2007) Stability of mRNA/DNA and DNA/DNA duplexes affects mRNA transcription, PLoS One. 2007 Mar 14;2(3)

Nedelcheva-Veleva MN, Krastev DB, Stoynov SS. (2006) Coordination of DNA synthesis and replicative unwinding by the S-phase checkpoint pathways. Nucleic Acids Res. 2006;34(15):4138-46

Mitkova E, Ugrinova I, Pashev IG, Pasheva EA. (2005), The inhibitory effect of HMGB-1 protein on the repair of cisplatin-damaged DNA is accomplished through the acidic domain.Biochemistry, 44:5893-8.

Pasheva E, Sarov M, Bidjekov K, Ugrinova I, Sarg B, Lindner H, Pashev IG (2004),  In vitro acetylation of HMGB-1 and -2 proteins by CBP: the role of the acidic tail. Biochemistry, 43: 2935-40.

Ugrinova I, Pasheva EA, Armengaud J, Pashev IG. (2001), In vivo acetylation of HMG1 protein enhances its binding affinity to distorted DNA structures. Biochemistry, 40:14655-60.

Pasheva EA, Pashev IG, Favre A. (1998), Preferential binding of high mobility group 1 protein to UV-damaged DNA. Role of the COOH-terminal domain.J Biol. Chem. 273:24730-6.