PROJECTS

Dynamic Changes in Replication Complex, funded by ICGEB (project No CRP/BGR16-03). 2017 – 2019. Principal investigator - Assoc. Prof. Marina Nedelcheva-Veleva, PhD
DNA repair function of the glycolytic enzyme glucose 6-phosphate isomerase.
Project Euro-BioImaging Preparatory Phase II ¹688945 financed by H2020-EU.1.4.1.1. The Institute of Molecular biology in partnership with 22 of the most elite scientific institutions in Europe and with coordinator The European Molecular Biologic Laboratory has won the project EuBI PPII (http://cordis.europa.eu/project/rcn/198825_en.html) for the construction of scientific infrastructure for excellence call H2020-INFRADEV-1-2015-2, "Developing new world-class research infrastructures".
The Institute of Molecular biology BAS is establishing a Center for modern microscopy in the field of fundamental and applied sciences, which is part of the EuroBioImaging consortium. The center is listed for establishment in the National Map for Scientific Infrastructure with decision of the Goverment of The Republic of Bulgaria ¹ 569/31.07.2014 with indicative budget for the construction– 445901 levas and 217148 levas annually for maintenance.
Development and implementation of Grouping and Safe-by-Design approaches within regulatory frameworks.,NanoReg2 - EU, H-2020 2015-2018. Project Leader: Prof. Margarita Apostolova
Ultrananocrystalline diamond coated implants for enhanced osteointegration. DAAD/NSF-BG DNTS/Germany 01/7. 2014-2015. Project Leader: Prof. Margarita Apostolova
Dynamics, mechanisms and order of binding of DNA repair proteins in living cells, funded by National Science Fund of Bulgaria (project No ÄÔÍÈ-Á02/16). 2014 – 2017. Principal investigator – Assoc. Prof. Stoyno Stoynov, PhD
A detailed study of the role of yeast linker histone Hho1p in the processes of chromatin remodeling; (DMU 02/8; 2009 - 2013). Funded by the Bulgarian National Science Fund. Project Leader: Assist. Prof. Milena Georgieva.
Environmental pollution impact on the ionomes of natural populations of plants for monitoring purposes. (DDVU 02/61; 2010 – 2015). Funded by The Bulgarian National Science Fund). Project Leader Prof. Rumyana Djingova in collaboration with Assoc. Prof. George Miloshev.
Study on some molecular mechanisms by which fragile X mental retardation protein 1 in Drosophila melanogaster (dFMRP1) controls neuronal development (DID 02/35; 2009 – 2013). Funded by The Bulgarian National Fund. Project leader Prof. Ginka Genova in collaboration with Assoc. Prof. George Miloshev.
The yeast Saccharomyces cerevisiae – a promising model for studying of human brain tumors; Funded by the World Federation of Scientists, National Scholarship Programme (2010 – 2011). Project Leader: Assist. Prof. Milena Georgieva
Bulgarian young people – educated and healthy citizens of Europe (BG13/A1.2/242/R2; 2013 – 2014), Funded by the "Youth In Action" Program, European Union. Project Leader Assoc. Prof. George Miloshev.
Safety evaluation of manufactured nanomaterials by characterization of their potential genotoxic hazard (N 20092101, 2010-2013). Funded by the EU, DG Sanco, Program Joint action. Principal Investigator: Assoc. Prof. Margarita Apostolova
Novel biodegradable nanostructured materials acceleration osteogenesis (DO1-1126, 2007-2013). Funded by the Bulgarian National Science Fund. Project Leader: Assoc. Prof. Margarita Apostolova
Physiological and pharmaco-biochemical effects of opioid peptide mimetics (2012-2013). Funded by Medical University - Varna, Bulgaria. Project Leader: Prof. Negrev in collaboration with Assoc. Prof. Tamara Pajpanova
Coordination of DNA synthesis and unwinding by replicative checkpoint (CPR/BUL10-03, 2010-2013). Funded by ICEGEB. Project Leader: Senior Research Associate Stoyno Stoynov
Expression level of HMGB1 protein and its receptor RAGE in human tumors and tumor cell lines with varying degrees of differentiation - a potential prognostic marker (DTK 02/80, 2010-2014).  Funded by the Bulgarian National Science Fund. Project Leader: Prof. Iliya Pashev
Mammalian INO80-class chromatin remodelers in genome integrity maintenance (CRP/12/005, 2012-2015). Funded by ICEGEB. Project Leader: Assoc. Prof. Anastas Gospodinov
Role of mammalian Ino80-class remodelers in the response to replication stress and their potential involvement in oncogenesis (MU 03-122, 2011-2013). Funded by the Bulgarian National Science Fund. Project Leader: Assoc.Prof. Anastas Gospodinov
Regulation of non-coding transcription in the human beta-globin locus (DFNI-B01/1, 2012-2015). Funded by the Bulgarian National Science Fund. Project Leader: Assoc. Prof. Lyubomira Chakalova
Development of peptidyle RNAs as sequence specific for DNA damages, genotoxic agents and diagnostic probes (DFNI – B01/20, 2012-2015). Funded by the Bulgarian National Science Fund. Project Leader: Prof. Tsvetan Ganchev
Application of the supercomputer BLUEGENE for evaluating the role of the host genome for changeability and adaptation of the flu virus A (PRP FP7 02/1). Funded by the Bulgarian National Science Fund and the NCSKP/FP7. Project Leader: Prof. Vera Maximova
Inactive analogues of hIFNg for treatmenmt of autoimmune diseases (Tigo-01/2006, 2006-2013).  Funded by TIGO GmbH (Heidelberg, Germany). Project Leader: Prof. Ivan Ivanov
Molecular design and construction of recombinant competitors of the human interferon-gamma: A new approach for treatment of autoimmune diseases (DID-02-30/09). Funded by the Bulgarian National Science Fund. Project Leader: Prof. Ivan Ivanov
DNA Repair: A new gene responsible for elimination of carbohydrate residues from DNA (DID-02-31/09). Funded by the Bulgarian National Science Fund. Project Leader: Assoc. Prof. Rumiana Mironova
Strcture-function relationship in protein and peptides (DRG 02/05). Funded by the Bulgarian National Science Fund. Project Leader: Prof. Andrei Karshokoff