DEPARTMENTS


Gene Regulation
 
Regulation of gene expression in heterologous systems; alternative initiation of translation in bacteria; expression of eukaryotic genes in bacterial hosts; post-translations modifications of the recombinant proteins; human cytokines; glycation in bacteria - structure and function relationship; bioinformatics and in silico modeling; applied research - development of human interferon-gamma based pharmaceuticals, environmental microbiology
 
Molecular biology of cell cycle
 
The objective of the Department is to study DNA replication, DNA repair and cell cycle signaling, key processes that maintain genome integrity and are among the main research topics in cancer biology.
 
Structure and function of chromatin
 
"Structure and function of chromatin" department develops several main topics: HMGB1 - a chromatin protein involved in cellular and extracellular signaling and its role in carcinogenesis and metastasis; To study the mechanisms of synchronization between different processes taking place during replication, repair and transcription of DNA; Genetic studies of ancient DNA;  Evaluation of the biological activity of newly synthesized compounds with potential application in pharmacy on cellular and animal models.
 
Biochemical pharmacology and drug design
 
Synthesis and mechanism of action of analogs of pyrimidines, purines, amino acids and neuropeptides, platinum complexis and other antitumor agents. Natural and synthetic inhibition of UDP-glucuronosyltransferase. Microbial diversity and activity in polluted environments.
    

The Laboratory of Yeast Molecular Genetics has strong background in multiple areas of modern Biology and Biomedicine. The research interests are in the field of Molecular Biology, Molecular Genetics and Epigenetics. Scientific work involves use of state-of-the art methodologies which aim at elucidation of the epigenetic mechanisms that regulate and control genome activity in norm and pathology.

 
Medical and Biological Research Laboratory
 
Development of cutting-edge research programs to address significant physiological and pathophysiological mechanisms and maintenance of an active linkage between basic and clinical investigators with research programs in atherosclerosis, cardiovascular biology, diabetes, cancer and nanotechnology.