DEPARTMENTS
Gene Regulation
Regulation of gene expression in heterologous systems; alternative initiation
of translation in bacteria; expression of eukaryotic genes in bacterial hosts;
post-translations modifications of the recombinant proteins; human cytokines;
glycation in bacteria - structure and function relationship; bioinformatics and
in silico modeling; applied research - development of human interferon-gamma based
pharmaceuticals, environmental microbiology
Molecular biology of cell cycle
The objective of the Department is to study DNA replication,
DNA repair and cell cycle signaling, key processes that maintain genome integrity and are among the main research topics
in cancer biology.
Structure and function of chromatin
"Structure and function of chromatin" department develops several main topics:
HMGB1 - a chromatin protein involved in cellular and extracellular signaling and
its role in carcinogenesis and metastasis; To study the mechanisms of synchronization
between different processes taking place during replication, repair and transcription
of DNA; Genetic studies of ancient DNA; Evaluation of the biological activity of newly synthesized compounds with potential
application in pharmacy on cellular and animal models.
Biochemical pharmacology and drug design
Our department uses a state-of-the-art and highly efficient technological platform
for drug design. It is not only applied to screening and evaluation of biological
activity, but also for estimation of diverse pharmacological parameters of new
chemical entities and natural compounds. We aim at the development of innovative
therapeutic and diagnostic agents.
Our department uses a state-of-the-art and highly efficient technological platform for drug design. It is not only applied to screening and evaluation of biological activity, but also for estimation of diverse pharmacological parameters of new chemical entities and natural compounds. We aim at the development of innovative therapeutic and diagnostic agents.
The
Laboratory of Yeast Molecular Genetics has strong background in multiple areas
of modern Biology and Biomedicine. The research interests are in the field of
Molecular Biology, Molecular Genetics and Epigenetics. Scientific work involves
use of state-of-the art methodologies which aim at elucidation of the
epigenetic mechanisms that regulate and control genome activity in norm and
pathology.
Medical and Biological Research Laboratory
Development of cutting-edge research programs to address significant physiological
and pathophysiological mechanisms and maintenance of an active linkage between
basic and clinical investigators with research programs in atherosclerosis, cardiovascular
biology, diabetes, cancer and nanotechnology.
The Laboratory of Yeast Molecular Genetics has strong background in multiple areas of modern Biology and Biomedicine. The research interests are in the field of Molecular Biology, Molecular Genetics and Epigenetics. Scientific work involves use of state-of-the art methodologies which aim at elucidation of the epigenetic mechanisms that regulate and control genome activity in norm and pathology.
Laboratory
of Genomic stability
In the laboratory of
"Genomic stability" by using a variety of high-tech methods of
molecular biology, biochemistry, bioinformatics and physics are explored the
mechanisms of synchronization between different processes taking place during
replication, repair and transcription of DNA.
Laboratory
of Genomic stability
In the laboratory of
"Genomic stability" by using a variety of high-tech methods of
molecular biology, biochemistry, bioinformatics and physics are explored the
mechanisms of synchronization between different processes taking place during
replication, repair and transcription of DNA.
