{"id":12424,"date":"2023-11-18T10:11:34","date_gmt":"2023-11-18T08:11:34","guid":{"rendered":"http:\/\/www.bio21.bas.bg\/ippg\/bg\/?page_id=12424"},"modified":"2023-11-18T10:13:43","modified_gmt":"2023-11-18T08:13:43","slug":"%d0%b3%d0%b4%d1%81-%d1%82%d0%b5%d0%bc%d0%b0%d1%82%d0%b8%d1%87%d0%bd%d0%be-%d0%bd%d0%b0%d0%bf%d1%80%d0%b0%d0%b2%d0%bb%d0%b5%d0%bd%d0%b8%d0%b5-4","status":"publish","type":"page","link":"http:\/\/www.bio21.bas.bg\/ippg\/bg\/?page_id=12424","title":{"rendered":"\u0413\u0414\u0421 &#8211; \u0422\u0435\u043c\u0430\u0442\u0438\u0447\u043d\u043e \u043d\u0430\u043f\u0440\u0430\u0432\u043b\u0435\u043d\u0438\u0435 4"},"content":{"rendered":"<h4 style=\"text-align: justify;\">4. \u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0438 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u0438 \u043d\u0430 \u043a\u0430\u043d\u0446\u0435\u0440\u043e\u0433\u0435\u043d\u0435\u0437\u0430\u0442\u0430<\/h4>\n<p style=\"text-align: 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\u0434\u0438\u043d\u0430\u043c\u0438\u043a\u0430 \u0438 \u0441\u0442\u0430\u0431\u0438\u043b\u043d\u043e\u0441\u0442\u201c \u0446\u0435\u043b\u044f\u0442 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u043d\u0435 \u043d\u0430 \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u043d\u0438\u044f \u0438 \u0435\u043f\u0438\u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u043d \u0441\u0442\u0430\u0442\u0443\u0441 \u043d\u0430 \u0440\u0435\u0434\u0438\u0446\u0430 \u0442\u0443\u043c\u043e\u0440\u043d\u043e \u0441\u0443\u043f\u0440\u0435\u0441\u043e\u0440\u043d\u0438 \u0433\u0435\u043d\u0438 \u0438 \u043f\u0440\u043e\u0442\u043e-\u043e\u043d\u043a\u043e\u0433\u0435\u043d\u0438 \u043f\u0440\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0438 \u0441 \u0440\u0430\u043a \u043d\u0430 \u043c\u043b\u0435\u0447\u043d\u0430\u0442\u0430 \u0436\u043b\u0435\u0437\u0430. \u0422\u044a\u0440\u0441\u044f\u0442 \u0441\u0435 \u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e\u0441\u0442\u0438 \u0441\u044a\u0441 \u0441\u0442\u0430\u0442\u0438\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0430 \u0437\u043d\u0430\u0447\u0438\u043c\u043e\u0441\u0442 \u043c\u0435\u0436\u0434\u0443 \u0430\u043d\u043e\u0440\u043c\u0430\u043b\u043d\u0438\u044f \u0433\u0435\u043d\u0435\u043d \u0441\u0442\u0430\u0442\u0443\u0441, \u043a\u043b\u0438\u043d\u0438\u0447\u043d\u0438\u0442\u0435 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0438 \u0438 \u043f\u0440\u0435\u0436\u0438\u0432\u044f\u0435\u043c\u043e\u0441\u0442\u0442\u0430 \u043d\u0430 \u0431\u043e\u043b\u043d\u0438\u0442\u0435.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-12428 size-full\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/bg\/wp-content\/uploads\/2023\/11\/gds-fig-11.png\" alt=\"\" width=\"425\" height=\"289\" \/><\/p>\n<p style=\"text-align: justify;\"><em>\u041f\u0440\u043e\u0447\u0435\u0442\u0435\u0442\u0435 \u043f\u043e\u0432\u0435\u0447\u0435:<\/em><\/p>\n<p style=\"text-align: justify;\">Antov, G, Krasteva, M, Andonova, S, Savov, A, Angelova, S, Stoilov, L, Toncheva, D. (2017) <em>STK11<\/em> gene mutations among patients with sporadic breast cancer. <em>Genetika<\/em>, 49, 2, 399-413. <a href=\"https:\/\/doi.org\/10.2298\/GENSR1702399A\">https:\/\/doi.org\/10.2298\/GENSR1702399A<\/a><\/p>\n<p style=\"text-align: justify;\">Krasteva, M, Angelova, S, Gospodinova, Z. (2014) Molecular-genetic aspects of breast cancer. <em>Acta Medica Bulgarica<\/em>, 41, 2, 67-79. <a href=\"https:\/\/doi.org\/10.1515\/amb-2014-0024\">https:\/\/doi.org\/10.1515\/amb-2014-0024<\/a><\/p>\n<p style=\"text-align: justify;\">Krasteva, M, Antov, G, Gospodinova, Z, Angelova, S, Nacheva, M, Georgieva, E, Gavrilov, I. (2014) Aberrant promoter methylation in <em>p53<\/em> and <em>ATM<\/em> genes was not associated with sporadic breast carcinogenesis in Bulgarian patients. <em>Journal of BioScience and Biotechnology<\/em>, 3, 2, 105-109.<\/p>\n<p style=\"text-align: justify;\">Angelova, S, Krasteva, M, Gospodinova, Z, Georgieva E. (2012) <em>CHEK2<\/em> gene alterations independently increase the risk of death from breast cancer in Bulgarian patients. <em>Neoplasma<\/em>, 59, 6, 622-630. <a href=\"https:\/\/doi.org\/10.4149\/neo_2012_079\">https:\/\/doi.org\/10.4149\/neo_2012_079<\/a><\/p>\n<p style=\"text-align: justify;\">Krasteva, M, Bozhanov, S, Antov, G, Gospodinova, Z, Angelova, S, Georgieva, E. (2012) Breast cancer patients with hypermethylation in the promoter of <em>BRCA1<\/em> gene exhibit favorable clinical status. <em>Neoplasma<\/em>, 59, 1, 85-91. <a href=\"https:\/\/doi.org\/10.4149\/neo_2012_011\">https:\/\/doi.org\/10.4149\/neo_2012_011<\/a><\/p>\n<p style=\"text-align: justify;\">Bozhanov, S, Angelova, S, Krasteva, M, Markov, Ts, Christova, S, Gavrilov, I, Georgieva E. (2010) Alterations in <em>p53<\/em>, <em>BRCA1<\/em>, <em>ATM<\/em>, <em>PIK3CA<\/em>, and <em>HER2<\/em> genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer. <em>Journal of Cancer Research and Clinical Oncology<\/em>, 136, 1657\u20131669. <a href=\"https:\/\/doi.org\/10.1007\/s00432-010-0824-9\">https:\/\/doi.org\/10.1007\/s00432-010-0824-9<\/a><\/p>\n<hr \/>\n<h6 style=\"text-align: right;\"><a class=\"_ps2id\" href=\"#top\" data-ps2id-offset=\"300\">[ Top ]<\/a><\/h6>\n","protected":false},"excerpt":{"rendered":"<p>4. \u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0438 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u0438 \u043d\u0430 \u043a\u0430\u043d\u0446\u0435\u0440\u043e\u0433\u0435\u043d\u0435\u0437\u0430\u0442\u0430 \u041a\u0430\u043d\u0446\u0435\u0440\u043e\u0433\u0435\u043d\u0435\u0437\u0430\u0442\u0430 \u0435 \u043c\u043d\u043e\u0433\u043e\u0441\u0442\u044a\u043f\u0430\u043b\u0435\u043d \u043f\u0440\u043e\u0446\u0435\u0441, \u043f\u0440\u0438 \u043a\u043e\u0439\u0442\u043e \u0441\u0435 \u043d\u0430\u0442\u0440\u0443\u043f\u0432\u0430\u0442 \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u043d\u0438 \u0438 \u0435\u043f\u0438\u0433\u0435\u043d\u0435\u0442\u0438\u0447\u043d\u0438 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u044f, \u043f\u043e\u0432\u043b\u0438\u044f\u0432\u0430\u0449\u0438 \u0435\u043a\u0441\u043f\u0440\u0435\u0441\u0438\u044f\u0442\u0430 \u043d\u0430 \u0433\u0435\u043d\u0438, \u0441\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u0441 \u043f\u0440\u043e\u0446\u0435\u0441\u0438\u0442\u0435 \u043d\u0430 \u043a\u043b\u0435\u0442\u044a\u0447\u043d\u043e \u0434\u0435\u043b\u0435\u043d\u0435, \u0414\u041d\u041a \u0440\u0435\u043f\u0430\u0440\u0430\u0446\u0438\u044f, \u0445\u0440\u043e\u043c\u043e\u0437\u043e\u043c\u043d\u0430 \u0441\u0435\u0433\u0440\u0435\u0433\u0430\u0446\u0438\u044f, \u043a\u043e\u043d\u0442\u0440\u043e\u043b \u0432\u044a\u0440\u0445\u0443 \u043a\u043b\u0435\u0442\u044a\u0447\u043d\u0438\u044f \u0446\u0438\u043a\u044a\u043b \u0438 \u043a\u043b\u0435\u0442\u044a\u0447\u043d\u0438\u0442\u0435 \u043e\u0442\u0433\u043e\u0432\u043e\u0440\u0438 \u0438 \u0434\u0440. \u0414\u0432\u0430 \u043e\u0441\u043d\u043e\u0432\u043d\u0438 \u043a\u043b\u0430\u0441\u0430 \u0433\u0435\u043d\u0438 \u0441\u0430 \u0430\u043d\u0433\u0430\u0436\u0438\u0440\u0430\u043d\u0438 \u0432 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u0438\u0442\u0435 \u043d\u0430 \u043a\u0430\u043d\u0446\u0435\u0440\u043e\u0433\u0435\u043d\u0435\u0437\u0430\u0442\u0430 \u2013 \u043f\u0440\u043e\u0442\u043e-\u043e\u043d\u043a\u043e\u0433\u0435\u043d\u0438 \u0438 \u0442\u0443\u043c\u043e\u0440\u043d\u043e \u0441\u0443\u043f\u0440\u0435\u0441\u043e\u0440\u043d\u0438 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":50,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"http:\/\/www.bio21.bas.bg\/ippg\/bg\/index.php?rest_route=\/wp\/v2\/pages\/12424"}],"collection":[{"href":"http:\/\/www.bio21.bas.bg\/ippg\/bg\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.bio21.bas.bg\/ippg\/bg\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.bio21.bas.bg\/ippg\/bg\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.bio21.bas.bg\/ippg\/bg\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12424"}],"version-history":[{"count":4,"href":"http:\/\/www.bio21.bas.bg\/ippg\/bg\/index.php?rest_route=\/wp\/v2\/pages\/12424\/revisions"}],"predecessor-version":[{"id":12431,"href":"http:\/\/www.bio21.bas.bg\/ippg\/bg\/index.php?rest_route=\/wp\/v2\/pages\/12424\/revisions\/12431"}],"up":[{"embeddable":true,"href":"http:\/\/www.bio21.bas.bg\/ippg\/bg\/index.php?rest_route=\/wp\/v2\/pages\/50"}],"wp:attachment":[{"href":"http:\/\/www.bio21.bas.bg\/ippg\/bg\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12424"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}