Lyubomir Stoilov

Prof. Dr. L. Stoilov

Professor Dr. Lyubomir Stoilov

Phone: +359-2-9746228 ext. 349

Е-mail: molgen@bas.bg, lstoilov@bas.bg

Born: October 25, 1950
Place of Birth: Sofia, Bulgaria.
Nationality: Bulgarian
Marital Status: Married

Private address: Hemus str. 82, Bldg. 62, Sofia 1574, Bulgaria. Phone 00359 (2) 738612

Office/Correspondence address: Bulgarian Academy of Sciences, Institute of Plant Physiology and Genetics, Department of Molecular Genetics, 1113 Sofia, Bulgaria.

Main research area:
Molecular and cytogentic mechanisms of mutation induction in eukaryotic genome. Genomic and gene-specific repair in plants. Genetic toxicology.

Additional interests:
Genome integrity. Genetic diversity in cereals. Mobile genetic elements in plants.

Specialized expertise:
Supervisor of Ph.D., graduate and post-graduate students. Lecturer at Sofia State University, Magister program of Genetics. Referee of scientific projects for Bulgarian National Science Fund, Bulgarian Patent Agency an International peer review journals.

Specialization and international contacts:

  • 1985-1986 12 months fellowship from the International Atomic Energy Agency (IAEA) at the Department of Radiation Genetics and Chemical Mutagenesis, Sylvius Laboratory, Medical Faculty, Leiden University, The Netherlands. Supervisor: Prof. A.T. Natarajan.
  • 1989 Visiting scientist for 2 months at the Department of Radiation Genetics and Chemical Mutagenesis, Sylvius Laboratory, Leiden University, The Netherlands.
  • 1991  Visiting scientist for two weeks at the Institute of Experimental Botany, Department of Genetics, Prague, Chech Republic. Host: Prof. J. Veleminsky
  • 1992   Visiting scientist for 2 weeks at Vienna University, Institute of Tumorbiology-Cancer Research, Department of Molecular Genetics, under the program “Forderung von Auslandsbeziehugen” of the University of Vienna, Austria. Host: Prof. U. Wintersberger.
  • 1994  Visiting scientist for 3 months at Leiden University, Department of Radiation Genetics and Chemical Mutagenesis. Fellowship from the European Community under the East-West exchange program. Host: Prof. A.T. Natarajan. Project: Effect of caffeine on radiation-induced DNA and chromosomal damage in human lymphocytes”
  • 1996 Invited speaker at the Institute of Tumorbiology and Cancer Research, Department of Molecular Genetics, University of Vienna, Austria. Host: Prof. U. Wintersberger, Seminar: Adaptive response to radiation-induced DNA and chromosomal damage in human peripheral blood lymphocytes.
  • 2001 Visiting scientists for 3 months at Essen University, Institute of Genetics, Essen, Germany. Short-Term EMBO Fellowship (European Molecular Biology Organization).  Host: Prof. G. Obe. Project: Comparative analyses of radiation- and restriction endonucleases-induced SCE and chromosomal aberrations in CHO cells.
  • 2003 Visiting scientists for 3 months at Essen University, Institute of Genetics, Essen, Germany. Short-Term EMBO Fellowship (European Molecular Biology Organization). Host: Prof. G. Obe.  Project: SCE induction in eukaryotic cells. Role of initial DNA damage and repair.
  • 2008 Visiting scientist for 3 months at Mainz University, Institute of Genetic Toxicology, Short Term DFG (German Research Foundation) fellowship, Host Prof. B. Kaina. Project: Evaluation of genotoxic DNA damage by the comet assay.
  • 2011 Scientific visit in the frames of the IAEA TC Project “Evaluation of natural and mutant genetic diversity in cereals by nuclear and molecular techniques” in Copenhagen State University, Faculty of Life Sciences, Department of Agriculture and Ecology, Host: Prof. S. K. Rasmussen, and Joint FAO/IAEA Agriculture and Biotechnology Laboratory, Seibersdorf, Austria, Plant Breeding and Genetics Section, Host: Prof. B. Till. Subject: Induced mutations and genomics techniques for cereal improvement with emphasis on TILLING and Ecotilling.

Education:

  • 1980-1984 Institute of Genetics, Bulgarian Academy of Sciences, Department of Experimental mutagenesis, P.h. D. Thesis: “Antimutagenic action of some radioprotectors in chemical mutagenesis”, 1984.
  • 1978 Graduation at Sofia State University, Biological Faculty, Department of Genetics. Magister Thesis: “Effect of caffeine on chemically induced chromosomal aberrations in barley (Hordeum vulgare L.)”.
  • 1964-1968 Secondary Polytechnic school, Sofia.

Professional Work History Chart:

  • 2011- Deputy Director of the Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences
  • 2008 -2010 – Deputy Director of the Institute of Genetics , Bulgarian Academy of Sciences
  • 2003 up to now – Head, Department of Molecular Genetics, Institute of Genetics and Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences.
  • 2001-2002 Deputy head of the Department of Molecular Genetics, Institute of Genetics, Bulgarian Academy of Sciences, Sofia, Bulgaria.
  • 1996-2001 Institute of Genetics, Bulgarian Academy of Sciences, Department of Molecular Genetics, Sofia, Bulgaria. Associate Professor, Molecular Genetics.
  • 1985-1996 Institute of Genetics, Bulgarian Academy of Sciences, Department of Molecular Genetics, Sofia, Bulgaria.  Research fellow, Molecular Genetics.
  • 1984-1985 Institute of Genetics, Bulgarian Academy of Sciences, Department of Experimental Mutagenesis, Supervisor: Prof. H. Nicoloff, Research Assistant
  • 1980-1984 Institute of Genetics, Bulgarian Academy of Sciences, Department of Experimental Mutagenesis, Sofia, Bulgaria. Supervisor: Prof. H. Nicoloff, Ph.D. student, Molecular Cytogenetics.
  • 1979-1980 Institute of Genetics, Bulgarian Academy of Sciences, Department of Experimental Mutagenesis, Sofia, Bulgaria. Supervisor: Prof. H. Nicoloff, Assistant, Cytogenetics.

Language Proficiency:
Mother tongue: Bulgarian
Other Languages:
English: Fluent Spoken, Written and Reading.
Russian: Fluent Written and Reading. Spoken: Working knowledge.

Other important information:
Total number of publications in a peer review journals: 56, 25 of them in International journals with IF, 5 in international journals without IF and 8 in Bulgarian journals with IF. Number of oral and poster presentations at international and national congresses and symposia – 22.

Project management: Chief scientific investigator of 2 international projects (IAEA funded), Participant in 2 international projects (NATO and IAEA funded), Chief scientific investigator and participant in several national projects (funded by the National Science Foundation of Bulgaria).

Member of the Bulgarian Scientific Union, Genetics section. Member of the National advisory council on the genetically modified organisms.

Member of the Editorial Board of Plant Mutation Reports, Open Toxicology Journal, Journal of Carcinogenesis and Mutagenesis, Journal of Genetics and Applied Physiology.

Supervisor of 5 PhD- students, 2 successfully defended and 2 under study. 5 successfully defended MS students.

Selected publications:
Stoilov L., M. Georgieva, V. Manova, L.Liu, K. Gecheff (2013). Karyotype reconstruction modulates the sensitivity of barley genome to radiation-induced DNA and chromosomal damage. Mutagenesis, vol. 28, 153–160.

Todorovska E.,. Dimitrova A, Stoilov L., Christov N., Vassilev D.and K. Gecheff (2013).   Molecular variability in barley structural mutants produced by gamma-irradiation. Plant Mutation Reports, in press.

Georgieva M, Stoilov L, Rancheva E, Todorovska E, Vassilev D (2011). Comparative Analysis of Data Distribution Patterns in Plant Comet Assay. Biotechnol. & Biotechnol. Eq. 24:2142-2148.

Ruffini Castiglione M, Venora G, Ravalli C, Gecheff K, Stoilov L, Cremonini R (2010) DNA methylation pattern in a barley reconstructed karyotype with deleted ribosomal gene cluster of chromosome 6H. Protoplasma, 242:13–18.

Manova V, Georgieva M, Borisov B, Stoilova B, Gecheff K, Stoilov L (2009) Genomic and gene-specific induction and repair of DNA damage in barley. Q.Y. Shu (ed.), Induced Plant Mutations in the Genomics Era. Food and Agriculture Organization of the United Nations, Rome, 133-136.

Stoilov L, Gecheff K (2009) Restriction endonucleases as a tool for in vivo induction of chromosomal and DNA damage in barley genome. Q.Y. Shu (ed.) Induced Plant Mutations in the Genomics Era. FAO, Rome, 235-238.

Ruffini Castiglione M, Venora G, Ravalli C, Stoilov L, Gecheff K, Cremonini R (2008) DNA methylation and genome rearrangements in barley reconstructed karyotypes. Protoplasma, 232: 215–222.

Bonchev G, Stoilov L, Todorovska E, Angelova Z, Kitanova M, Georgiev S (2008) Characterization of AC-transposon-homologous sequences in wheat genome. Plant GEM 2008, Albena, Bulgaria, Oral presentation S05.4.

Dimitrova A, Ananiev E, Stoilov L, Gecheff K (2008) Ribosomal RNA Gene Expression in Reconstructed Barley Karyotypes, Compt. Rend. Acad. Bulg. Sci  61:1159-1168.

Georgieva M, Manova V, Liu L, Stoilov L (2008) Induction of DNA damage by Li-ions and gamma rays in barley genome. Poster presentation IAEA-CN-167-075, FAO/IAEA International Symposium on Induced Mutations in Plants, Vienna, Austria.

Georgieva M, Stoilov L. (2008). Assessment of DNA strand breaks induced by bleomycin in barley by the comet assay. Environmental and Molecular Mutagenesis, 49:381-387.

Stoilov LM, Mullenders LHF, Darroudi F, Natarajan AT (2007) Adaptive response to DNA and chromosomal damage induced by X-rays in human blood lymhocytes. Mutagenesis, 22:117-122.

Manova V, Gecheff K, Stoilov L (2006) Efficient repair of bleomycin-induced double-strand breaks in barley ribosomal genes. Mutation Research, 601:179-190.

Wojcik A, Stoilov L, Szumiei I, Legerski R, Obe G (2005) Rad51C-deficient CL-V4B cells exhibit normal levels of mitomycin C-induced SCE but reduced levels of UVC-induced SCEs.  Biochemical and Biophysical Research Communications, 326:805-810.

Manova V, Stoilov L (2005) Repair of DNA double-strand breaks in eukaryotic genome. Genetics and Breeding, 34:39-61.

Manova VI, Stoilov L (2003) Induction and recovery of double-strand breaks in barley ribosomal DNA. DNA Repair, 2:983-990

Stoilov L Wojcik A, Giri A, Obe G (2002) SCE formation after exposure of CHO cells pre-labelled with BrdU or biotin-dUTP to various DNA damaging agents. Mutagenesis, 17:399-403.

Venora G, Stoilov L, Gecheff K, Cremonini R (2002) CHIAS-based positioning of recombination hot-spots and Giemsa bands in a multireconstructed barley karyotype. Caryologia,  55:99-103.

Stoilov L, Darroudi F, Meschini R, Van Der Schans G, Mullenders LHF, Natarajan AT (2000) Inhibition of repair of X-ray induced DNA double-strand breaks in human blood lymphocytes exposed to sodium butyrate. Int. J. Rad. Biol., 76:1485-1491.

Stoilov LM, Mirkova V, Gecheff K (2000) Hae III induces position-dependent chromosomal breakage in barley (Hordeum vulgare L.) Mutagenesis, 15:277-279.

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