{"id":237,"date":"2012-03-30T09:51:36","date_gmt":"2012-03-30T06:51:36","guid":{"rendered":"http:\/\/www.bio21.bas.bg\/ippg\/en\/?page_id=237"},"modified":"2026-01-26T13:10:20","modified_gmt":"2026-01-26T11:10:20","slug":"molecular-genetics","status":"publish","type":"page","link":"http:\/\/www.bio21.bas.bg\/ippg\/en\/?page_id=237","title":{"rendered":"LABORATORY &#8220;GENOME DYNAMICS AND STABILITY&#8221;"},"content":{"rendered":"<table border=\"0\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td valign=\"top\" width=\"220\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-13997 size-medium\" style=\"border: 1px solid grey; border-radius: 9px; box-shadow: 1px 1px 3px #717070;\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/bg\/wp-content\/uploads\/2026\/01\/Bonchev-Georgi-300x293.jpg\" alt=\"\" width=\"300\" height=\"293\" \/><\/td>\n<td width=\"313\">\n<h4 style=\"text-align: center;\">Leader<strong><br \/>\n<\/strong><\/h4>\n<h5 style=\"text-align: center;\">Associate Professor Georgi Bonchev, PhD<strong><br \/>\n<\/strong><\/h5>\n<p style=\"text-align: center;\">Building 21, Office 106<br \/>\nPhone: +359 2 979 2678;<br \/>\n\u0415-mail: georgi.bonchev71@gmail.com<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Field of Research<\/h2>\n<p style=\"text-align: justify;\">The laboratory unit is engaged in fundamental and applied research addressing various topics on genetic and epigenetic mechanisms implicated in genome dynamics and functioning in eukaryotic organisms in natural and stress-induced environment.<\/p>\n<p style=\"text-align: justify;\">The main research areas in the laboratory are:<\/p>\n<ul>\n<li style=\"text-align: justify;\">Molecular mechanisms of DNA damage repair and tolerance to environmental stress in the genome of cultivated plants.<\/li>\n<li style=\"text-align: justify;\">Development of chromosome and DNA markers for genome identification and assessment of natural and mutant genetic diversity in plants.<\/li>\n<li style=\"text-align: justify;\">Molecular mechanisms of carcinogenesis. Antitumor potential of medicinal and aromatic plants.<\/li>\n<li style=\"text-align: justify;\">Epigenetic regulation of gene expression.<\/li>\n<\/ul>\n<h2><a href=\"http:\/\/www.bio21.bas.bg\/ippg\/en\/?page_id=3059\">Ongoing Research Projects<\/a><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2677 alignleft\" style=\"margin-right: 10px;\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/en\/wp-content\/uploads\/2022\/02\/enter-14-32.png\" alt=\"\" width=\"20\" height=\"20\" \/><\/h2>\n<h2><a href=\"http:\/\/www.bio21.bas.bg\/ippg\/en\/?page_id=3072\">Research Topics<\/a><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2677 alignleft\" style=\"margin-right: 10px;\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/en\/wp-content\/uploads\/2022\/02\/enter-14-32.png\" alt=\"\" width=\"20\" height=\"20\" \/><\/h2>\n<h2><a href=\"http:\/\/www.bio21.bas.bg\/ippg\/en\/?page_id=1814\">Scientific Publications<\/a><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2677 alignleft\" style=\"margin-right: 10px;\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/en\/wp-content\/uploads\/2022\/02\/enter-14-32.png\" alt=\"\" width=\"20\" height=\"20\" \/><\/h2>\n<hr \/>\n<h4><strong>Lab facilities<\/strong><\/h4>\n<p style=\"text-align: justify;\">The unit has in possession two main laboratories for high-throughput research in molecular genetics (lab. 211 and 221). Another one lab is at the stage of preparation for entering into functionning (lab. 514).<\/p>\n<p style=\"text-align: center;\">Laboratory 211<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-12373\" style=\"border: 1px solid grey; border-radius: 9px; box-shadow: 1px 1px 3px #717070;\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/bg\/wp-content\/uploads\/2023\/11\/gds-lab-211.png\" alt=\"\" width=\"650\" height=\"159\" \/><br \/>\nLaboratory 221<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-12375\" style=\"border: 1px solid grey; border-radius: 9px; box-shadow: 1px 1px 3px #717070;\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/bg\/wp-content\/uploads\/2023\/11\/gds-lab-221.png\" alt=\"\" width=\"650\" height=\"161\" \/><br \/>\nLaboratory 514<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-12377\" style=\"border: 1px solid grey; border-radius: 9px; box-shadow: 1px 1px 3px #717070;\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/bg\/wp-content\/uploads\/2023\/11\/gds-lab-514.jpg\" alt=\"\" width=\"214\" height=\"161\" \/><\/p>\n<h2>Research Team<\/h2>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<table border=\"0\" width=\"640\" cellspacing=\"0\" cellpadding=\"5\">\n<tbody>\n<tr style=\"text-align: justify;\">\n<td style=\"border-bottom: 1px dotted #cccccc;\" valign=\"top\" width=\"130\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-14001\" style=\"border: 1px solid grey; border-radius: 9px; box-shadow: 1px 1px 3px #717070;\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/bg\/wp-content\/uploads\/2026\/01\/Bonchev-G_th.jpg\" alt=\"\" width=\"92\" height=\"113\" \/><\/td>\n<td style=\"border-bottom: 1px dotted #cccccc;\" width=\"510\"><span style=\"font-weight: bold; text-shadow: #cacaca 0.5px 0.5px;\"><a href=\"http:\/\/www.bio21.bas.bg\/ippg\/en\/?page_id=2186\">Georgi Bonchev &#8211; Associate Professor, PhD<\/a><\/span><br \/>\nBuilding 21, Office 106, Lab. 211, 221<br \/>\nPhone: +359 (2) 979 2678<br \/>\nE-mail: <a href=\"mailto:georgi.bonchev71@gmail.com\">georgi.bonchev71@gmail.com<\/a><br \/>\n<em>Professional interests<\/em>: DNA molecular markers, DNA barcoding; Transposable elements \u2013 structure, function and regulation; Development and application of DNA molecular markers with emphasis on transposable elements for the assessment of the natural and stress-induced genetic diversity; Population genetics, micro-evolutionary changes and ecology.<\/td>\n<\/tr>\n<tr style=\"text-align: justify;\">\n<td style=\"border-bottom: 1px dotted #cccccc;\" valign=\"top\" width=\"130\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-10268\" style=\"border: 1px solid grey; border-radius: 9px; box-shadow: 1px 1px 3px #717070;\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/bg\/wp-content\/uploads\/2020\/06\/manova-v_th.jpg\" alt=\"\" width=\"92\" height=\"113\" \/><\/p>\n<\/td>\n<td style=\"border-bottom: 1px dotted #cccccc;\" width=\"510\"><span style=\"font-weight: bold; text-shadow: #cacaca 0.5px 0.5px;\"><a href=\"http:\/\/www.bio21.bas.bg\/ippg\/en\/?page_id=2364\">Vasilissa Manova &#8211; Assistant Professor, PhD<\/a><\/span><\/p>\n<p>Building 21, Office 106, Lab. 211, 221<br \/>\nPhone: +359 (2) 974 2678<br \/>\nE-mail: <a href=\"mailto:vmanova@bas.bg\">vmanova@bas.bg<\/a><br \/>\n<em>Professional interests<\/em>: Molecular mechanisms of DNA damage response in plants: Genomic and gene-specific DNA repair in barley; Gene expression profiling of barley under genotoxic stress (UV radiation, environmental pollution, etc.); Molecular detection and characterization of fungal pathogens in crop plants; DNA barcoding and metabarcoding of plants and fungi.<\/td>\n<\/tr>\n<tr style=\"text-align: justify;\">\n<td style=\"border-bottom: 1px dotted #cccccc;\" valign=\"top\" width=\"130\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-12382\" style=\"border: 1px solid grey; border-radius: 9px; box-shadow: 1px 1px 3px #717070;\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/bg\/wp-content\/uploads\/2023\/11\/Irina-Boycheva_th.jpg\" alt=\"\" width=\"92\" height=\"113\" \/><\/td>\n<td style=\"border-bottom: 1px dotted #cccccc;\" width=\"510\">\n<h5>Irina Boycheva &#8211; Assistant Professor, PhD<\/h5>\n<p>Building 21, \u041effice 117, Lab. 211, 221<br \/>\nPhone: +359 (2) 979 2689<br \/>\ne-mail: <a href=\"mailto:irina_boycheva@bio21.bas.bg\">irina_boycheva@bio21.bas.bg<\/a><br \/>\n<em>Professional interests<\/em>: DNA barcoding and metabarcoding \u2013 plants, algae, fungi, databasing, epigenetics; regulation of gene expression; functional and comparative genomics in model plants.<\/td>\n<\/tr>\n<tr style=\"text-align: justify;\">\n<td style=\"border-bottom: 1px dotted #cccccc;\" valign=\"top\" width=\"130\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-2036 size-full\" style=\"border: 1px solid grey; border-radius: 9px; box-shadow: 1px 1px 3px #717070;\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/en\/wp-content\/uploads\/2020\/01\/s-simeonova.jpg\" alt=\"\" width=\"92\" height=\"113\" \/><\/p>\n<\/td>\n<td style=\"border-bottom: 1px dotted #cccccc;\" width=\"510\">\n<h5>Stiliana Simeonova &#8211; PhD student<\/h5>\n<p>Office 234 (Build. 23), lab. 211, 221<br \/>\nPhone: +359 (2) 979 2617<br \/>\nE-mail: <a href=\"mailto:steli_sim@abv.bg\">steli_sim@abv.bg<\/a><br \/>\n<em>Professional interests:<\/em> Expression of target genes in psychoactive substance use disorder.<\/td>\n<\/tr>\n<tr style=\"text-align: justify;\">\n<td style=\"border-bottom: 1px dotted #cccccc;\" valign=\"top\" width=\"130\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-7567\" style=\"border: 1px solid grey; border-radius: 9px; box-shadow: 1px 1px 3px #717070;\" title=\"nikolova-i\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/bg\/wp-content\/uploads\/2011\/03\/nikolova-i.jpg\" alt=\"\" width=\"92\" height=\"113\" \/><\/td>\n<td style=\"border-bottom: 1px dotted #cccccc;\" width=\"510\">\n<h5>Ivelina Nikolova &#8211; <strong>Researcher, MSc<\/strong><\/h5>\n<p>Building 25, Lab. 322 A<br \/>\nPhone: +359 (2) 979 3673<br \/>\nE-mail: <a href=\"mailto:ivahilator@abv.bg\">ivahilator@abv.bg<\/a><br \/>\n<em>Professional interests<\/em>: DNA barcoding of plants and fungi; DNA damages and repair; Molecular-cytogenetics characterization of plant species; DNA markers and fluorescent in situ hybridization; Position-specific effects in barley chromosomes; Chromosome aberrations; Abiotic stress; Statistical analyses.<\/td>\n<\/tr>\n<tr style=\"text-align: justify;\">\n<td style=\"border-bottom: 1px dotted #cccccc;\" valign=\"top\" width=\"130\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-7568\" style=\"border: 1px solid grey; border-radius: 9px; box-shadow: 1px 1px 3px #717070;\" title=\"nikolov-i\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/bg\/wp-content\/uploads\/2011\/03\/nikolov-i.jpg\" alt=\"\" width=\"92\" height=\"115\" \/><\/td>\n<td style=\"border-bottom: 1px dotted #cccccc;\" width=\"510\">\n<h5>Ilija Nikolov &#8211; <strong>Researcher, MSc<\/strong><\/h5>\n<p>Building 25, Lab. 322 A<br \/>\nPhone: +359 (2) 979 3673<br \/>\nE-mail: <a href=\"mailto:ilija_nik@mail.bg\">ilija_nik@mail.bg<\/a><br \/>\n<em>Professional interests<\/em>: Molecular markers; Bioinformatics and computer technologies.<\/td>\n<\/tr>\n<tr style=\"text-align: justify;\">\n<td style=\"border-bottom: 1px dotted #cccccc;\" valign=\"top\" width=\"130\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-13999\" style=\"border: 1px solid grey; border-radius: 9px; box-shadow: 1px 1px 3px #717070;\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/bg\/wp-content\/uploads\/2026\/01\/Gospodinova-Z_th.jpg\" alt=\"\" width=\"107\" height=\"113\" \/><\/td>\n<td style=\"border-bottom: 1px dotted #cccccc;\" width=\"510\">\n<h5>Zlatina Gospodinova &#8211; Assistant Professor, PhD<\/h5>\n<p>Office 122, lab. 221<br \/>\nPhone: +359 (2) 979 2617<br \/>\nE-mail: <a href=\"mailto:zlatina.go@abv.bg\">zlatina.go@abv.bg<\/a><br \/>\n<em>Professional interests:<\/em> Antitumor activity and pharmacological potential of medicinal and aromatic plants; Molecular mechanisms of antitumor effect; Genetic and epigenetic mechanisms of carcinogenesi.<\/td>\n<\/tr>\n<tr style=\"text-align: justify;\">\n<td style=\"border-bottom: 1px dotted #cccccc;\" valign=\"top\" width=\"130\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-7574\" style=\"border: 1px solid grey; border-radius: 9px; box-shadow: 1px 1px 3px #717070;\" title=\"antov-g\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/bg\/wp-content\/uploads\/2011\/03\/antov-g.jpg\" alt=\"\" width=\"92\" height=\"113\" \/><\/td>\n<td style=\"border-bottom: 1px dotted #cccccc;\" width=\"510\">\n<h5>Georgi Antov &#8211; Assistant Professor, PhD<\/h5>\n<p>Office 122, lab. 221<br \/>\nPhone: (+359 2) 979 2617<br \/>\nE-mail: <a href=\"mailto:antov8107@abv.bg\">antov8107@abv.bg<\/a><br \/>\n<em>Professional interests:<\/em> Genetic and epigenetic mechanisms in carcinogenesis; Antitumor potential of medicinal and aromatic plants; Nutrigenetics.<\/td>\n<\/tr>\n<tr style=\"text-align: justify;\">\n<td style=\"border-bottom: 1px dotted #cccccc;\" valign=\"top\" width=\"130\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-7572\" style=\"border: 1px solid grey; border-radius: 9px; box-shadow: 1px 1px 3px #717070;\" title=\"taseva-t\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/bg\/wp-content\/uploads\/2011\/03\/taseva-t.jpg\" alt=\"\" width=\"92\" height=\"113\" \/><\/td>\n<td style=\"border-bottom: 1px dotted #cccccc;\" width=\"510\">\n<h5>Teodora Taseva &#8211; Assistant Professor, PhD<\/h5>\n<p>Building 21, Office 109, lab. 211, 221<br \/>\n\u0422\u0435\u043b: +359 (2) 973 2690<br \/>\n\u0415-mail: <a href=\"mailto:tasevatk@bio21.bas.bg\">tasevatk@bio21.bas.bg<\/a><br \/>\n<em>Professional interests<\/em><em>: <\/em>Molecular genetics, Epigenetic regulation of gene expression, DNA methylation, de novo and maintaining DNA methyltransferases, imprinted genes, studies on the effects of substances on obesity in animals, embryonic development, statistics models of mediation and moderation.<\/td>\n<\/tr>\n<tr style=\"text-align: justify;\">\n<td style=\"border-bottom: 1px dotted #cccccc;\" valign=\"top\" width=\"130\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-2037 size-full\" style=\"border: 1px solid grey; border-radius: 9px; box-shadow: 1px 1px 3px #717070;\" src=\"http:\/\/www.bio21.bas.bg\/ippg\/en\/wp-content\/uploads\/2020\/01\/y-koycheva.jpg\" alt=\"\" width=\"92\" height=\"113\" \/><\/p>\n<\/td>\n<td style=\"border-bottom: 1px dotted #cccccc;\" width=\"510\">\n<h5>Yana Koicheva &#8211; Researcher, MSc<\/h5>\n<p>Office 234 (Build. 23), lab. 211, 221<br \/>\nPhone: +359 (2) 979 2617<br \/>\nE-mail: <a href=\"mailto:yana.koicheva@gmail.com\">yana.koicheva@gmail.com<\/a><br \/>\n<em>Professional interests:<\/em> Epigenetic mechanisms of programming and reprogramming of the genome in eukaryotic organisms; Mechanisms of regulation of imprinted genes; Epigenetic changes in mouse parthenogenesis.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h6 style=\"text-align: right;\"><a class=\"_ps2id\" href=\"#top\" data-ps2id-offset=\"300\">[ Top ]<\/a><\/h6>\n","protected":false},"excerpt":{"rendered":"<p>Leader Associate Professor Georgi Bonchev, PhD Building 21, Office 106 Phone: +359 2 979 2678; \u0415-mail: georgi.bonchev71@gmail.com Field of Research The laboratory unit is engaged in fundamental and applied research addressing various topics on genetic and epigenetic mechanisms implicated in genome dynamics and functioning in eukaryotic organisms in natural and stress-induced environment. The main research [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":30,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"http:\/\/www.bio21.bas.bg\/ippg\/en\/index.php?rest_route=\/wp\/v2\/pages\/237"}],"collection":[{"href":"http:\/\/www.bio21.bas.bg\/ippg\/en\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.bio21.bas.bg\/ippg\/en\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.bio21.bas.bg\/ippg\/en\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.bio21.bas.bg\/ippg\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=237"}],"version-history":[{"count":82,"href":"http:\/\/www.bio21.bas.bg\/ippg\/en\/index.php?rest_route=\/wp\/v2\/pages\/237\/revisions"}],"predecessor-version":[{"id":1712,"href":"http:\/\/www.bio21.bas.bg\/ippg\/en\/index.php?rest_route=\/wp\/v2\/pages\/237\/revisions\/1712"}],"up":[{"embeddable":true,"href":"http:\/\/www.bio21.bas.bg\/ippg\/en\/index.php?rest_route=\/wp\/v2\/pages\/30"}],"wp:attachment":[{"href":"http:\/\/www.bio21.bas.bg\/ippg\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}