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Kamen Koumanov
Phone: +359-2-9719628; +359-2-9792623
Fax: +359-2-9712493
1937 Born August 2, Stara Zagora
1960 MS, Agricultural Academy, Sofia
1972 PhD in Biology
1977 Associate Professor
1987 DSc in Biology
1988 Professor
2003 Doctor Honoris Causa, University “Pierre et Marie Curie”, Paris, France
2003 Academician
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blue_but.gif (1076 bytes)Selected Publications 

Georgieva R., Mircheva K., Vitkova V., Balashev K., Ivanova T., Tessier C., Koumanov K., Nuss P., Momchilova A., Staneva G. Phospholipase A2 induced remodeling processes on liquid-ordered/liquid-disordered membranes containing docosahexaenoic or oleic acid: a comparison study Langmuir 2016, 32, 1756-1770.

Momchilova A., Petkova D., Staneva G., Markovska T., Pankov R., Skrobanska R., Nikolova-Karakashian M., Koumanov K. Resveratrol alters the lipid composition, metabolism and peroxide level in senescent rat hepatocytes, Chemico-Biological Interactions 2014, 207,74-80.(PDF)

Hazarosova, R., Petkova, D., Staneva, G., Koumanov, K., Momchilova, A. Resveratrol modulates the lipid ordering in model membranes, FEBS JOURNAL 2016, 283, 289-289, Supplement: 1, Special Issue: SI

Georgieva R., Momchilova A., Petkova D, Koumanov K., Staneva G. (2013) Effect of n-propyl galate on lipid peroxidation in heterogenous model membranes. Biotechnol. & Biotechnol. Eq. 27, 4145-4149.(PDF)

Galya Staneva, Albena Momchilova, Kamen Koumanov, Miglena I. Angelova, Developing Cell-Scale Biomimetic Systems: A Tool for Understanding Membrane Organization and Its Implication in Membrane - Associated Pathological Processes, In: Advances in Planar Lipid Bilayers and Liposomes, Elsevier, 2013, Vol.17, pp.167-213.(PDF)

Staneva G., Lupanova T., Chachaty C., Petkova D., Koumanov K., Pankov R., Momchilova A. (2011) Structural organization of plasma membrane lipids isolated from cells cultured as a monolayer and in tissue-like conditions - J. Colloid & Interface Sci. 2011, 359, 202–209.(PDF)

Georgieva R., Koumanov K., Momchilova A., Tessier C., Staneva G. (2010) Effect of sphingosine on domain morphology in giant vesicles. - J. Colloid & Interface Sci., 50, 502-510.(PDF)

Lupanova T., Stefanova N., Petkova D., Staneva G., Jordanova A., Koumanov K., Pankov R., Momchilova A. (2010) Alterations in the content and the physiological role of sphingomyelin and cholesterol in plasma membranes of cells cultured in three-dimensional matrix. - Mol. Cell Biochem., 340, 215-222.(PDF)

Staneva G., Momchilova A., Wolf C., Quinn P.J., Koumanov K. (2009) Membrane microdomains: Role of ceramides in the maintenance of their structure and functions. - Biochim. Biophys. Acta-Biomembranes 1788, 666–675.(PDF)

Staneva G., Chachaty C., Wolf C., Koumanov K., Quinn P.J. (2008) The role of sphingomyelin in regulating phase coexistence in complex lipid model membranes: competition between ceramide and cholesterol. - Biochim. Biophys. Acta-Biomembranes 1778, 2727-2739. (PDF)

Staneva G., Seigneuret M., Koumanov K., Trugnan G., Angelova M. I. (2005) Detergents induce raft-like domains budding and fission from giant unilamellar heterogeneous vesicles A direct microscopy observation. Chemistry and Physics of Lipids 136 , 55-66. (PDF)

Quinn P. J., Tessier C., Rainteau D., Koumanov K. S., Wolf C. (2005) Structure and thermotropic phase behaviour of detergent-resistant membrane raft fractions isolated from human and ruminant erythrocytes. Biochimica et Biophysica Acta 1713, 5-14. (PDF)

Koumanov K. S., Tessier C., Momchilova A. B., Rainteau D., Wolf C., Quinn P. J. (2005) Comparative lipid analysis and structure of detergent-resistant membrane raft fractions isolated from human and ruminant erythrocytes. Archives of Biochemistry and Biophysics 434, 150–158. (PDF)

Tessier C. Quinn P.J., Koumanov K., Trugnan G., Reinteau D., Wolf C. (2004) Modulation of the phase heterogeneity of aminoglycerophopholipid mixtures by sphingomyelin and monovalent cations: maintenance of the lamellar arrangement in the biological membranes. Eur. Biophys. J. 33,513-521. (PDF)

Staneva G., Angelova M.I., Koumanov K. (2004)Phospholipase A2 Promotes Raft Budding and Fission from Giant Liposomes. Chem. Phys. Lipids 129, 53-62. (PDF)

Bailleux A., Wendum D., Audubert F., Jouniaux A. M., Koumanov K., Trugnan G., Masliah J.(2004) Cytosolic phospholipase A2/p11 interaction controls arachidonic acid release as a function of epithelial cell confluence. Biochem J. 378, 307-315. (PDF)

Staneva G., Momchilova A., Angelova M., Koumanov K. (2004) Regulatory effect of sphingolipids on secretory phospholipase A2. A comparative study using SUV and GUV. C.R. Acad. Bulg. Sci 57,(1), 59-64. (PDF)

Koumanov K., Momchilova A., Wolf C. (2003) Bimodal regulatory effect of melittin and phospholipase A2-activating protein on human type II secretory phospholipase A2. Cell Biol. Int.27, 871-877. (PDF)

Chabot S., Koumanov K., Lambeau., Gelb M. H., Balloy V., Chignard M., Whitsett J.A., Touqui L. (2003) Inhibitory effect of surfactant protein A on surfactant phospholipids hydrolysis by secreted phospholipases A 2. J. Immunol. 171, 995-1000.(PDF)

Attalah H. L., Wu., Alaoui El Azher M., Thouron F., Koumanov K., Wolf C., Brochard L., Harf A., Delclaux C., Touqui L.(2003) Eur. Respir. J. 21, 1040-1045. (PDF)

Ledoux S., Runembert I., Koumanov K., Michel J. B., Trugnan G., Fridlander G. (2003) Hypoxia enhances ecto-5’-nucleotidase activity and cell surface expression in endothelial cells. Role of membrane lipids – Circ. Res. 92, 848-855.(PDF)

Koumanov K.S., Momchilova A B., Quinn P.J., Wolf C. (2002) Ceramides increase the activity of the secretory phospholipase A2 and alter its fatty acid specificity – Biochem. J. 363, 45-51. (PDF)

Wolf C., Koumanov K., Tenchov B., Quinn P.J. (2001) Cholesterol favors phase separation of sphingomyelin – Biophys. Chem. 89, 163-172. (PDF)

Klapisz E., Masliah., Bereziat G., Wolf C., Koumanov K. S.(2000) Sphingolipids and cholesterol modulate membrane susceptibility to cytosolic phospholipase A 2 – J Lipid Res. 41, 1680-1688.(PDF)

Wolf C., Quinn P., Koumanov K., Chachaty C., Tenchov B. (1999) Arrangement physique des lipides membranaires susceptibles d’être utilisés par les processus d’adressage cellulaire des protéines – Soc. Biol. 193, 1-6. (PDF)

Couturier C., Brouillet A., Couriaud C., Koumanov K., Béréziat G., Andréani M. (1999) Interleukin 1b induces type-II-secreted phospholipase A2 gene in vascular smooth muscle cells by a nuclear factor k B-and peroxisome proliferator activated receptor-mediated process – J. Biol. Chem. 274, 23085-23093. (PDF)

Klapisz E., Ziari M., Wendum D., Koumanov K., Brachet-Ducos C., Olivier J.-L., Bereziat G., Trugnan G., Masliah J. (1999) N- and C-terminal plasma membrane anchoring modulate differently agonist-induced activation of cytosolic phospholipase A2 – Eur. J. Biochem. 265, 957-966.(PDF)

Arbibe L., Koumanov K.S., Vial D., Rougeot C., Faure G., Havet N., Longacre S., Vargaftig B., Béréziat G., Voelker D.R., Wolf C., Touqui L. (1998) Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interaction - J. Clin. Invest. 102, 1152-1160. (PDF)

Cane A., Breton M., Koumanov K., Béréziat G., Colard O. (1998) Oxidant-induced arachidonic acid release and impairment of fatty acid acylation on vascular smooth muscle cells - Am. J. Physiol. 274, C1040-C1046. (PDF)

Koumanov K.S., Quinn P.J., Béréziat G., Wolf C. (1998) Cholesterol relieves the inhibitory effect of sphingomyelin on type II secretory phospholipase A2 - Biochem. J. 336, 625-630. (PDF)

Koumanov K., Wolf C., Béréziat G. (1997) Modulation of human type II secretory phospholipase A2 by sphingomyelin and annexin VI - Biochem. J. 326, 227-233. (PDF)

Cupillard L., Koumanov K., Mattei M.G., Lazdunski M., Lambeau G. (1997) Cloning, chromosomal mapping and expression of a novel human secretory phospholipase A2 - J. Biol. Chem. 272, 15745-15752. (PDF)

Momchilova-Pankova A.B., Markovska T.T., Koumanov K.S. (1995) Acyl-CoA synthetase activity depends on the phospholipid composition of rat liver plasma membranes - J. Lipid Mediators Cell Signalling 11, 13-23.

Koumanov K.S., Momchilova-Pankova A.B., Markovska T.T., Quinn P.J., Wolf C. (1995) Phospholipids with a short acyl chain modulates phospholipase and acyltransferase activities - J. Lipid Mediators Cell Signalling 12, 59-76.

Momchilova-Pankova A.B., Markovska T.T., Yanev E.I., Koumanov K.S. (1994) Phospholipase C activity in rat liver plasma membranes depends on the phospholipid composition - J. Lipid Mediators 9, 235-246.

Gavrilova N.J., Setchenska M.S. Markovska T.T., Momchilova- Pankova A.B., Koumanov K.S. (1993) Effect of membrane phospholipid composition and fluidity on rat liver plasma membrane tyrosine kinase activity - Int. J. Biochem. 25, 1309-1312.

Nikolova-Karakashian N.N., Petkova D.H., Koumanov K.S. (1992) Influence of cholesterol on sphingomyelin metabolism and hemileaflet fluidity of rat liver plasma membranes - Biochimie 74, 153-159.

Koshlukova S.E., Momchilova-Pankova A.B., Markovska T.T., Koumanov K.S. (1992) Phospholipid dependence of rat liver microsomal acyl:CoA synthetase and acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase - J. Membrane Biol. 127, 113-119.

Gavrilova N.J., Markovska T.T., Momchilova-Pankova A.B., Setchenska M.S., Koumanov K.S. (1992) Phospholipid-dependence of rat liver plasma membrane protein kinase activities - a new approch - Biochim. Biophys. Acta 1105, 328-332.

Nikolova M.N., Petkova D.H., Koumanov K.S. (1992) Influence of phospholipid environment on the phosphatidylethanolamine: ceramide-phosphorylethanolamine transferase activity in rat liver plasma membranes - Int. J. Biochem. 24, 447-453.

Koshlukova S.E., Markovska T.T., Momchilova A.B., Pankov R.G., Koumanov K.S. (1992) Alterations in microsomal and plasma membranes during liver regeneration - Biochimie 74, 981-987.

Yanev E., Markovska T., Momchilova A., Pankov R., Sedloev T., Koumanov K. (1992) Alterations in rat alveolar surfactant system induced by treatment with carbicron /O-[(2-butenoic acid)-N,N-dimethylamide-3-YL] O,O-dimethyl-phosphate/ - Comp. Biochem. Physiol. 103C, 553-555.

blue_but.gif (1076 bytes)Other Publications

blue_but.gif (1076 bytes)Citations of the publications of Acad. Kamen Koumanov

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