“GENOME DYNAMICS AND STABILITY” – Scientific Publications


Antov G, Vilhelmova-Ilieva N, Nikolova M, Nikolova I, Simeonova L, Grozdanov P, Krasteva M, Vladimirova A, Gospodinova Z. 2023. In vitro evaluation of anticancer, antiviral, and antioxidant properties of an aqueous methanolic extract of Rhus typhina L. leaves. International Food Research Journal, 30, 774-782. https://doi.org/10.47836/ifrj.30.3.19

Gospodinova Z, Antov G, Novakovic M, Tesevic V, Krasteva N, Pavlov D, Valcheva-Kuzmanova S. 2023. Antiproliferative activity of natural flavonoid fustin isolated from the heartwood of Cotinus coggygria Scop. against breast and colon cancer cell lines. Acta Medica Bulgarica, 50, 1, 27-33. https://doi.org/10.2478/amb-2023-0004

Dobrikova A, Gospodinova Z, Stefanov M, Apostolova E, Krasteva N. 2023. Phytochemical analysis and assessment of the antioxidant activity and cytotoxicity potential of hydroethanolic extract of Bulgarian Sideritis scardica. Journal of Chemical Technology and Metallurgy, 58, 1, 93-100.

Ivanova D, Toneva M, Simeonov E, Nikolova B, Semkova S, Antov G, Yaneva Z. 2023. Newly Synthesized Lignin Microparticles as Bioinspired Oral Drug-Delivery Vehicles: Flavonoid-Carrier Potential and In Vitro Radical-Scavenging Activity. Pharmaceutics, 15, 4, 1067. https://doi.org/10.3390/pharmaceutics15041067

Semkova S, Nikolova B, Tsoneva I, Antov G, Ivanova D, Angelov A, Zhelev Z, Bakalova R. 2023. Redox-mediated anticancer activity of anti-parasitic drug fenbendazole in triple-negative breast cancer cells. Anticancer Research, 43, 3, 1207-1212. https://doi.org/10.21873/anticanres.16267


Aneva I, Zhelev P, Bonchev G. 2022. Sideritis elica, a new species of Lamiaceae from Bulgaria, revealed by morphology and molecular phylogeny. Plants, 11, 2900. https://doi.org/10.3390/plants11212900

Aneva I, Zhelev P, Bonchev G, Boycheva I, Simeonova S, Kancheva D. 2022. DNA Barcoding Study of Representative Thymus Species in Bulgaria. Plants, 11(3), 270. https://doi.org/10.3390/plants11030270

Petrova D, Gašić U, Yocheva L, Hinkov A, Yordanova Z, Chaneva G, Mantovska D, Paunov M, Ivanova L, Rogova M, Shishkova K, Todorov D, Tosheva A, Kapchina-Toteva V, Vassileva V, Atanassov A, Mišić D, Bonchev G, Zhiponova M. 2022. Catmint (Nepeta nuda L.) Phylogenetics and Metabolic Responses in Variable Growth Conditions. Front Plant Sci., 13:866777. https://doi.org/10.3389/fpls.2022.866777

Korchanová Z, Švec M, Janáková E, Lampar A, Majka M, Holušová K, Bonchev G, Juračka J, Cápal P, Valárik M. 2022. Identification, High-Density Mapping, and Characterization of New Major Powdery Mildew Resistance Loci From the Emmer Wheat Landrace GZ1. Front Plant Sci., 13; 13:897697. https://doi: 10.3389/fpls.2022.897697

Chaneva G, Tomov A, Paunov M, Hristova V, Ganeva V, Mihaylova N, Anev S, Krumov N, Yordanova Z, Tsenov B, Vassileva V, Bonchev G, Zhiponova M. 2022. Jewel Orchid’s Biology and Physiological Response to Aquaponic Water as a Potential Fertilizer. Plants, 11, 3181. https://doi.org/10.3390/plants11223181

Krumov N, Hristova V, Bonchev G, Nedelcheva A, Tomov A, Zhiponova M. 2022. Review on Biological and Biotechnological Characteristics of the Terrestrial Orchid Ludisia discolor. Annu. Sofia Univ. “St. Kliment Ohridski” Fac. Biol. Book 2—Bot., 106, 13-30.

Manova V, Stoyanova Z, Rodeva R, Boycheva I, Korpelainen H, Vesterinen E, Wirta H, Bonchev G. 2022. Morphological, Pathological, and Genetic Diversity of Colletotrichum Species Pathogenic on Solanaceous Vegetable Crops in Bulgaria. Journal of Fungi. https://doi.org/10.3390/jof8111123

Nikolova E, Georgiev C, Laleva L, Milev M, Spiriev T, Stoyanov S, Taseva T, Mitev V, Todorova A. 2022. Diagnostic, grading and prognostic role of a restricted miRNAs signature in primary and metastatic brain tumours. Discussion on their therapeutic perspectives. Mol Genet Genomics, 297(2):357-371.


Tancheva L, Lazarova M, Velkova L, Dolashki A, Uzunova D, Minchev B, Petkova-Kirova P, Hassanova Y, Gavrilova P, Tasheva K, Taseva T, Hodzhev Y, Atanasov A, Stefanova M, Alexandrova A, Kalfin R, Dolashka P. 2022. Beneficial effects of snail Helix aspersa extract in experimental model of Alzheimer’s type dementia. J Alzheimers Dis., 88(1):155-175. http://doi.org/10.3233/JAD-215693

Taseva T, Koycheva Y, Simeonova S, Nikolova E, Krasteva M. 2022. GAPDH shows altered gene expression in alcohol models. Acta Medica Bulgarica, 49 (2). http://doi.org/10.2478/AMB-2022-0014


Boycheva I, Georgieva R, Stoilov L, Manova V. 2021. Effects of light and UV-C radiation on the transcriptional activity of COP1 and HY5 gene homologues in barley. Mutation Breeding, Genetic Diversity and Crop Adaptation to Climate Change, CABI Publishing, 478-486. https://doi.org/10.1079/9781789249095.00

Georgieva M, Bonchev G, Zehirov G, Vasileva V, Vassileva V. 2021. Neonicotinoid insecticides exert diverse cytotoxic and genotoxic effects on cultivated sunflower. Environmental Science and Pollution Research, 28, 38, 53193-53207. https://doi.org/10.1007/s11356-021-14497-y

Gospodinova Z, Kamenska T, Genchev, G, Georgieva M, Krasteva N. 2021. PEGylation of graphene oxide nanosheets modulate cancer cell motility and proliferative ability. Journal of Physics: Conference Series. https://doi.org/10.1088/issn.1742-6596

Gospodinova Z, Nikolova M, Antov G. 2021. In vitro antiproliferative effects of Cotinus coggygria Scop. on human non-melanoma and melanoma skin cancer cells. American Journal of Pharmacy &Health Research, 9, 7, 12-21.

Georgieva M, Gospodinova Z, Keremidarska-Markova M, Kamenska T, Gencheva G, Krasteva N. 2021. PEGylated nanographene oxide in combination with near-Infrared laser irradiation as a smart nanocarrier in colon cancer targeted therapy. Pharmaceutics, 13, 3, 424. https://doi.org/10.3390/pharmaceutics13030424

Haroun A, Gospodinova Z, Krasteva N. 2021. Amino Acid Functionalization of Multi-Walled Carbon Nanotubes for Enhanced Apatite Formation and Biocompatibility. Nano Biomedicine and Engineering, 13, 4, 380-393. https://doi.org/10.5101/nbe.v13i4.p380-393

Iantcheva A, Zhiponova M, Revalska M, Heyman J, Dincheva I, Badjakov I, Geyter ND, Boycheva I, Goormachtig S, Veylder LD. 2021. A common F‑box gene regulates the leucine homeostasis of Medicago truncatula and Arabidopsis thaliana. Protoplasma, https://doi.org/10.1007/s00709-021-01662-w

Semkova S, Antov G, Iliev I, Tsoneva I, Lefterov P, Christova N, Nacheva L, Stoineva I, Kabaivanova L, Staneva G, Nikolova B. 2021. Rhamnolipid Biosurfactants—Possible Natural Anticancer Agents and Autophagy Inhibitors. Separations, 8, 7, 92. https://doi.org/10.3390/separations8070092


Gospodinova Z, Zupkó I, Bózsity N, Manova V, Georgieva M, Todinova S, Taneva S, Ocsovszki I, Krasteva M. 2020. Cotinus coggygria Scop. induces cell cycle arrest, apoptosis, genotoxic effects, thermodynamic and epigenetic events in MCF7 breast cancer cells. Zeitschrift fur Naturforschung C. https://doi.org/10.1515/znc-2020-0087

Krasteva M, Koycheva Y, Taseva T, Simeonova S. 2020. Changes in the expression of DNA methylation related genes in leukocytes of persons with alcohol and drug dependence. Acta Medica Bulgarica, 47, 4, 11-17. https://doi.org/10.2478/amb-2020-0039

Krasteva M, Koycheva Y, Racheva R, Taseva T, Raycheva Ts, Simeonova S, Andreev B. 2020. Decreased FMR1 mRNA levels found in men with substance use disorders. Heliyon, 6, 10. https://doi.org/10.1016/j.heliyon.2020.e05270

Krasteva M. 2020. On the new prospects in biology inspired by epigenetics. Biomedical Reviews, 31, 31-39. http://dx.doi.org/10.14748/bmr.v31.7702

Nikolova B, Antov G, Semkova S, Tsoneva I, Christova N, Nacheva L, Kardaleva P, Angelova S, Stoineva I, Ivanova J, Vasileva I, Kabaivanova L. 2020. Bacterial natural disaccharide (Trehalose Tetraester): molecular modeling and in vitro study of anticancer activity on breast cancer cells. Polymers, 12, 2. http://dx.doi.org/10.3390/polym12020499

Vilhelmova N, Simeonova L, Nikolova N, Pavlova E, Gospodinova Z, Antov G, Galabov A, Nikolova I. 2020. Antiviral, cytotoxic and antioxidant effects of Tanacetum vulgare L. crude extract in vitro. Folia Medica, 62, 1, 172-179. https://doi.org/10.3897/folmed.62.e49370


Bonchev G, Vassilevska-Ivanova R. 2019. Fingerprinting the genetic variation and intergeneric hybrid dynamics in the family Asteraceae (genera Helianthus, Echinaceae, Tagetes and Verbesina) using iPBS markers. Biologia, 75, 4. https://doi.org/10.2478/s11756-019-00363-3

Bonchev G, Dušinský R, Hauptvogel H, Gaplovská-Kyselá K, Švec M. 2019. On the diversity and origin of the barley complex agriocrithon inferred by iPBS transposon markers. Genetic Resources and Crop Evolution, 66, 7, 1573-1586. https://doi.org/10.1007/s10722-019-00814-5

Taseva T, Koycheva Y, Olova N. 2019. Differential effects on mouse embryonal and placental imprinted H19 expression following ethanol exposure during implantation. Scientific Works of the Union of Scientists in Bulgaria – Plovdiv, Vol.ХХIII, 282-285.

Taseva T, Koycheva Y, Olova N. 2019. Long-lasting effect on the embryogenesis and Igf2 expression following in vitro ethanol exposure during preimplantation. Comptes rendus de l’Acad´emie bulgare des Sciences, 72, 12.

Nikolova B, Semkova S, Tsoneva I, Antov G, Ivanova J, Vasileva I, Kardaleva P, Stoineva I, Christova N, Nacheva L, Kabaivanova L. 2019. Characterization and potential antitumor effect of a heteropolysaccharide produced by the red alga Porphyridium sordidum. Engineering in Life Sciences, 19, 12, 978-985. https://doi.org/10.1002/elsc.201900019


Bonchev G, Willi Y. 2018. Accumulation of transposable elements in selfing populations of Arabidopsis lyrata supports the ectopic recombination model of transposon evolutio. New Phytologist, 219, 2, 767-778. https://doi.org/10.1111/nph.15201

Serbezov D, Balabanski L, Nikolova D, Hadjidekova S, Staneva R, Кarachanak-Yankova S, Mihaylova M, Damyanova V, Antov G, Vazharova R, Toncheva D. 2018. Variants in genes related to oncogenesis and cardiovascular diseases in supercentenarians. Modern medicine, 62, 1, 3-8.


Antov G, Krasteva M, Andonova S, Savov A, Angelova S, Stoilov L, Toncheva D. 2017. STK11 gene mutations among patients with sporadic breast cancer. Genetika, 49, 2, 399-413.

Bonchev G, Dusinsky R, Hauptvogel P, Svec M. 2017. Patterns of evolutionary trajectories and domestication history within the genus Hordeum assessed by REMAP markers. Journal of Molecular Evolution, 8, 2-3, 116-128. https://doi.org/10.1007/s00239-016-9779-z

Boycheva I, Vassileva V, Revalska M, Zehirov G, Iantcheva A. 2017. Different functions of the histone acetyltransferase HAC1 gene traced in the model species Medicago truncatula, Lotus japonicus and Arabidopsis thaliana. Protoplasma, 254, 2, 697-711. http://doi.org/10.1007/s00709-016-0983-x

Gospodinova Z, Krasteva M, Manova V. 2017. Effects of Cotinus coggygria extract on the transcriptional levels of histone deacetylase genes in breast cancer cells in vitro. American Journal of Pharmacy and Health Research, 5, 8, 60-69.

Gospodinova Z, Krasteva M. 2017. Cotinus coggygria Scop. leaf extract exerts high but not dose and time dependent in vitro cytotoxic activity on human breast cancer cells. Genetics and Plant Physiology, 7, 3-4.

Gospodinova Z, Bózsity N, Nikolova M, Krasteva M, Zupkó I. 2017. Antiproliferative properties against human breast, cervical and ovarian cancer cell lines, and antioxidant capacity of leaf aqueous ethanolic extract from Cotinus coggygria Scop. Acta Medica Bulgarica, 44, 2, 20-25. https://doi.org/10.1515/amb-2017-0014

Stoilov L, Manova V, Gecheff K. 2017. Cytogenetic and molecular aspects of the experimental mutagenesis in barley. Scientific works, Institute of Agriculture, Karnobat.

Taseva T, Koycheva Y, Olova N. 2017. Elevated Igf2 expression and enhanced mouse blastocyst development following in vitro exposure to ethanol. Genetics and Plant Physiology, 7, 3-4, 195-206.


Bonchev G, Shtereva L, Vassilevska-Ivanova R. 2016. Crosstalk between genetic diversity among inbred lines of sweet corn (Zea mays var. saccharata) and hybrid performance assessed by REMAP markers. Материалы международной научно-практической конференции «Научно-образовательная среда как основа развития агропромышленного комплекса и социальной инфраструктуры села», А. Е. Макушев. – Чебоксары : ФГБОУ ВО Чувашская ГСХА.

Bonchev G, Stereva L, Vassilevska-Ivanova R. 2016. Retrotransposon-related genetic distance among inbred lines of sweet corn (Zea mays var. saccharata) and hybrid performance. Plant Genetic Resources, 5, 5, 1-9. https://doi.org/10.1017/S1479262116000411

Bonchev G. 2016. Useful parasites: the evolutionary biology and biotechnology applications of transposable elements. Journal of Genetics, 95, 31, 1039-1052. https://doi.org/10.1007/s12041-016-0702-6

Koycheva Y, Taseva T, Popova S, Penkov L. 2016. Exogenous progesterone alters the expression of some growth related imprinted genes in mouse placenta. Comptes rendus de l’Academie bulgare des Sciences, 69, 3, 303-310.

Manova V, Georgieva R, Borisov B, Stoilov L. 2016. Efficient removal of cyclobutane pyrimidine dimers in barley: differential contribution of light-dependent and dark DNA repair pathways. Physiologia Plantarum, 158, 2, 236-253. https://doi.org/10.1111/ppl.12446

Rodeva R, Stoyanova Z, Manova V, Georgieva R, Stoilov L. 2016. Isolation and characterization of Colletotrichum coccodes from potato in Bulgaria. Acta Horticulturae, 1142, 127-134. https://doi.org/10.17660/ActaHortic.2016.1142.20

Iantcheva A, Revalska M, Zehirov G, Boycheva I, Magne K, Radkova M, Ratet P, Vassileva V. 2016. Tnt1 retrotransposon as an efficient tool for development of an insertional mutant collection of Lotus japonicus. In Vitro Cell. Dev. Biol. – Plant, 52, 338-347. http://doi.org/10.1007/s11627-016-9768-3


Boycheva I, Vassileva V, Revalska, M, Zehirov G, Iantcheva A. 2015. Cyclin-like F-box protein plays a role in growth and development of the three model species Medicago truncatula, Lotus japonicus and Arabidopsis thaliana. Research and Reports in Biology, 6, 117-130. https://doi.org/10.2147/RRB.S84753

Georgieva M, Nikolova I, Bonchev G, Katerova Z, Todorova D. 2015. A comparative analysis of membrane intactness and genome integrity in pea, barley and wheat in response to UVC-irradiation. Turkish Journal of Botany, 39, 6, 1008-1013. https://doi.org/10.3906/bot-1502-14

Georgieva M, Stoilov L. 2015. Neutral comet profiles: reliable system for analyses of DNA strand breaks distribution. Genetics and Plant Physiology, 5, 1, 10-14.

Gospodinova Z, Krasteva M. 2015. Cichorium intybus L. from Bulgaria inhibits viability of human breast cancer cells in vitro. Genetics and Plant Physiology, 5, 1, 15-22.

Gospodinova Z, Bózsity N, Ocsovszki I, Orbán-Gyapai O, Krasteva M, Zupkó I. 2015. Chloroformic fraction of Tanacetum vulgare L. induces cell cycle arrest and apoptosis in MCF7 cells. International Journal of Pharma Sciences, 5, 2, 986-990.

Koycheva Y, Taseva T, Popova S, Stoimenova D, Penkov L. 2015. Effects of progesterone on the expression of growth-related imprinted genes Igf2, H19 and Grb10 in the mouse placenta. Genetics and Plant Physiology, 5, 1, 86-93.

Manova V, Georgieva R, Georgieva M, Nikolova I, Gecheff K, Stoilov L. 2015. DNA and chromosomal damage as a hallmark of the induced genomic instability in barley. Genetics and Plant Physiology, 5, 3-4, 231-246.

Manova V, Gruszka D. 2015. DNA damage and repair in plants – from models to crops. Frontiers in Plant Science, 6:885. https://doi.org/10.3389/fpls.2015.00885

Nikolova I, Georgieva M, Kruppa K, Molnár-Láng M, Liu L, Manova V, Stoilov L. 2015. Cytogenetic effects in barley root apical meristem after exposure of dry seeds to lithium ion beams. Genetics and Plant Physiology, 5, 1, 3-9.

Taseva T, Penkov L, Koycheva Y, Stoimenova D, Popova S. 2015. Ethanol exposure during gestation alters Igf2 expression in developing mouse embryos. Genetics and Plant Physiology, 5, 1, 94-101.

Taseva T, Koycheva Y, Olova N, Popova S, Penkov L. 215. Effects of alcohol on placental growth and Igf 2 expression. Comptes rendus de l’Acad´emie bulgare des Sciences, 68, 9, 1107-1112.

Iantcheva A, Boycheva I, Revalska M. 2015. Development of root tips synchronized system for the model legume Medicago truncatula upon replication stress. Bulgarian Journal of Agricultural Science, 21, 6, 1177-1184.


Boycheva I, Vassileva V, Iantcheva A. 2014. Histone acetyltransferases in plant development and plasticity. Current Genomics, 15, 1, 28-37. https://doi.org/10.2174/138920291501140306112742

Gospodinova Z, Antov G, Angelova S, Krasteva M. 2014. In vitro antitumor potential of Bulgarian Tanacetum vulgare L. on human breast adenocarcinoma cells. International Journal of Pharma Sciences, 4, 2, 468-472.

Krasteva M, Antov G, Gospodinova Z, Angelova S, Nacheva M, Georgieva E, Gavrilov I. 2014. Aberrant promoter methylation in p53 and ATM genes was not associated with sporadic breast carcinogenesis in Bulgarian patients. Journal of BioScience and Biotechnology, 3, 2, 105-109.

Krasteva M, Angelova S, Gospodinova Z. 2014. Molecular-genetic aspects of breast cancer. Acta Medica Bulgarica, 41, 2, 67-79. https://doi.org/10.1515/amb-2014-0024

Balabanski L, Antov G, Dimova I, Ivanov S, Nacheva M, Gavrilov I, Nesheva D, Rukova B, Hadjidekova S, Malinov M, Toncheva D. 2014. Next‑generation sequencing of BRCA1 and BRCA2 in breast cancer patients and control subjects. Molecular and Clinical Oncology, 2, 3, 435-439. https://doi.org/10.3892/mco.2014.251


Bonchev G, Parisod C. 2013. Transposable elements and microevolutionary changes in natural populations. Molecular Ecology Resources, 13, 765-775. https://doi.org/10.1111/1755-0998.12133

Georgieva M, Nikolova I, Stoilov L, Katerova Z, Todorova D. 2013. Analysis of UVC-induced DNA damage on mono- and dicotyledonous species by comet assay. Jubilee National Scientific Conference with international participation “Traditions, directions, challenges”, Plovdiv University “Paisii Hilendarski”, Filial – Smolyan, II, I, Plovdiv University “Paisii Hilendarski”, Filial – Smolyan, 54-60.

Nikolova I, Georgieva M, Stoilov L, Katerova Z, Todorova D. 2013. Optimization of Neutral Comet Assay for studying DNA double-strand breaks in pea and wheat. Journal of BioScience and Biotechnology, 2, 3, PLOVDIV UNIVERSITY PRESS “PAISII HILENDARSKI”, 151-157.

Nikolova I, Georgieva M, Stoilov L, Katerova Z, Todorova D. 2013. The Comet assay as an indicator test for DNA integrity on plant species. Jubilee National Scientific Conference with international participation “Traditions, directions, challenges”, Plovdiv University “Paisii Hilendarski”, Filial – Smolyan, II, I, Plovdiv University “Paisii Hilendarski”, Filial – Smolyan, 46-53.

Stoilov L, Georgieva M, Manova V, Liu L, Gecheff K. 2013. Karyotype reconstruction modulates the sensitivity of barley genome to radiation-induced DNA and chromosomal damage. Mutagenesis, 28, 2, 1-8. https://doi.org/10.1093/mutage/ges065

Stoyanova Z, Rodeva R, Karov I, Kovacevik B, Manova V, Georgieva R. 2013. Morphological and molecular characterization of Colletotrichum coccodes isolated from pepper cultivated in Bulgaria and Macedonia. Matica Srpska Journal of Natural Sciences, 124, 124. https://doi.org/10.2298/ZMSPN1324249S

Angelova S, Gospodinova Z, Krasteva M, Antov G, Lozanov V, Markov T, Bozhanov S, Georgieva E, Mitev V. 2013. Antitumor activity of Bulgarian herb Tribulus terrestris L. on human breast cancer cells. Journal of Bioscience and Biotechnology, 2, 1, 25-32.

Todorovska E, Dimitrova A, Stoilov L, Christov N, Vassilev D, Gecheff K. 2013. Molecular variability in barley structural mutants produced by gamma-irradiation. Plant Mutation Rep., 3, 1, 4-8.


Bonchev G, Stoilov L, Angelova Z, Georgiev S. 2012. Genomic diversity of Ac-like transposable elements in sphaerococcum mutant forms of common wheat (T. aestivum L.) and triticale (X Triticosecale Witt.). Journal of Applied Genetics, 53, 1, 9-17. https://doi.org/10.1007/s13353-011-0065-x

Krasteva M, Bozhanov S, Antov G, Gospodinova Z, Angelova S, Georgieva E. 2012. Breast cancer patients with hypermethylation in the promoter of BRCA1 gene exhibit favorable clinical status. Neoplasma, 59, 1, 85-91. https://doi.org/10.4149/neo_2012_011

Manova V, Singh SK, Iliakis G. 2012. Processing of DNA double strand breaks by alternative non-homologous end-joining in hyperacetylated chromatin. Genome integrity, 3, 4. https://doi.org/10.1186/2041-9414-3-4

Rodeva R, Karov I, Stoyanova Z, Kovacevik B, Manova V, Georgieva R. 2012. Phomopsis capsici and Colletotrichum coccodes infecting pepper in Macedonia. Proceedings of the International Symposium on Current Trends in Plant Protection, Belgrade, Serbia, 257-263.

Stoyanova Z, Rodeva R, Manova V, Stoilov L, Mijatovic M. 2012. Unusual Colletotrichum sp. associated with pepper fruit anthracnose in Bulgaria and Serbia – preliminary results. Proceedings of the International Symposium on Current Trends in Plant Protection, Belgrade, Serbia, 299-306.

Angelova S, Krasteva M, Gospodinova Z, Georgieva E. 2012. CHEK2 gene alterations independently increase the risk of death from breast cancer in Bulgarian patients. Neoplasma, 59, 6, 622-630. https://doi.org/10.4149/neo_2012_079

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