Kiril Mishev

Associate Professor Kiril Mishev, PhD

Building 21, Office 117; Lab 112
Phone: +359-2-9792689; +359-2-979-2685

ORCID: 0000-0001-5849-8786
SCOPUS Author ID: 24373959400
Web of Science ResearcherID: Q-2631-2017


Plant endomembrane trafficking, plant hormone signal transduction, chemical genetics, regulation of the chloroplast gene expression, functional organization of the photosynthetic apparatus.


  • 2005-2009: Ph.D. in Plant Physiology, Institute of Plant Physiology and Genetics at the Bulgarian Academy of Sciences, Sofia, Bulgaria
  • 2003-2004: Master in Plant Physiology, Faculty of Biology, Sofia University, Bulgaria
  • 1999-2003: Bachelor in Molecular Biology, Faculty of Biology, Sofia University, Bulgaria


Bulgarian (mother tongue); English and Spanish – very good level


  • Short-term research visits in the University of Hohenheim, Stuttgart, Germany (2018), and the Institute of Experimental Botany at the Czech Academy of Sciences, Prague, Czech Republic (2018 and 2019);
  • Post-doctoral specialization in the Department of Plant Systems Biology at the Flanders Institute for Biotechnology, Ghent, Belgium (2014-2015) funded by BASF SE;
  • Post-doctoral specialization in the Department of Plant Systems Biology at the Flanders Institute for Biotechnology, Ghent, Belgium (2010-2012) funded by the Flemish Agency for Innovation by Science and Technology (IWT);
  • Pre-doctoral specialization in the Institute of Plant Physiology at the Martin-Luther University Halle-Wittenberg, Germany (01.06-30.11.2007) funded by the German Academic Exchange Service (DAAD).


  • Joint Research Project № КП-06-Индия-9 (Bulgaria-India), National Science Fund at the Bulgarian Ministry of Education and Science, 2019-2021;
  • Grant № ДН11/8, National Science Fund at the Bulgarian Ministry of Education and Science, 2018-2021;
  • Grant № ДН06/9, National Science Fund at the Bulgarian Ministry of Education and Science, 2017-2020;
  • Grant № ДН06/12, National Science Fund at the Bulgarian Ministry of Education and Science, 2017-2020;
  • Joint Research Project VS.078.18N between the Bulgarian Academy of Sciences and Research Foundation – Flanders (FWO), Belgium, 2018-2020.
  • Grant № ДФНИ БО2/18, National Science Fund at the Bulgarian Ministry of Education and Science, 2015-2017;
  • Joint Research Project VS.095.16N between the Bulgarian Academy of Sciences and Research Foundation – Flanders (FWO), Belgium, 2016-2018.
  • Joint research project between the VIB Department for Plant Systems Biology and BASF SE, 2014-2016;
  • Joint research project VS.025.13N between the Bulgarian Academy of Sciences and the Research Foundation – Flanders (FWO), 2013-2015;
  • Project BG051PO001-3.3.06-0025 within the Operational Programme “Human Resources Development” 2007 – 2013 framework (operation BG051PO001-3.3-06 started by the Bulgarian Ministry of Education and Science), 2012-2014;
  • Joint research project IWT095148 between the VIB Department for Plant Systems Biology and CropDesign N.V. (a BASF Plant Science company) funded by the Flemish Agency for Innovation by Science and Technology, 2010-2012.


  • Union of Scientists in Bulgaria
  • Federation of European Societies of Plant Biology (FESPB)


  • Frontiers in Plant Science (Plant Membrane Traffic and Transport section): Review Editor;
  • Plants MDPI (Plant Response to Abiotic Stress and Climate Change Section): Section Editorial Board member.


Total number of publications: 26
Publications with WoS IF: 22
Total IF (Web of Science): 115.8
Citations: > 420 (WoS and Scopus); > 550 (Google Scholar)

Mishev K., Dobrev P.I., Lacek J., Filepova R., Yuperlieva-Mateeva B., Kostadinova A., Hristeva T., 2021. Hormonomic changes driving the negative impact of broomrape on plant host interactions with arbuscular mycorrhizal fungi. International Journal of Molecular Sciences, 22(24): 13677. IF: 5,924 (2020).

Vaseva I.I., Simova-Stoilova L., Kirova E., Mishev K., Depaepe T., Van Der Straeten D., Vassileva V., 2021. Ethylene signaling in salt-stressed Arabidopsis thaliana ein2-1 and ctr1-1 mutants – A dissection of molecular mechanisms involved in acclimation. Plant Physiology and Biochemistry, 167: 999-1010. IF 4,270 (2020).

Vaseva I.I., Mishev K., Depaepe T., Vassileva V., Van Der Straeten D., 2021. The diverse salt-stress response of Arabidopsis ctr1-1 and ein2-1 ethylene signaling mutants is linked to altered root auxin homeostasis. Plants, 10(3): 452. IF 3,935 (2020).

Ananieva K., Gesheva E., Mishev K., Stanilova M., 2020. Antioxidant capacity of two endemic Verbascum species. Compt. Rend. Acad. Bulg. Sci, 73(6): 809-815. IF: 0,378 (2020).

Georgiev O., Mishev K., Krasnikova M., Kitanova M., Dimitrova A., Karagyozov L., 2019. The Hordeum bulbosum 25S-18S rDNA region: comparison with Hordeum vulgare and other Triticeae. Zeitschrift für Naturforschung C, 74(11-12): 319-328. IF 1,238 (2019).

Dejonghe W., Sharma I., Denoo B., De Munck S., Lu Q., Mishev K., Bulut H., Mylle E., De Rycke R., Vasileva M., Savatin D.V., Nerinckx W., Staes A., Drozdzecki A., Audenaert D., Yperman K., Madder A., Friml J., Van Damme D., Gevaert K., Haucke V., Savvides S.N., Winne J., Russinova E., 2019. Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nature Chemical Biology, 15(6): 641-649. IF 12,587 (2019).

Kania U., Nodzynski T., Lu Q., Hicks G.R., Nerinckx W., Mishev K., Peurois F., Cherfils J., De Rycke R.M., Grones P., Robert S., Russinova E., Friml J., 2018. The inhibitor Endosidin 4 targets SEC7 domain-type ARF GTPase exchange factors and interferes with subcellular trafficking in eukaryotes. The Plant Cell, 30(10): 2553-2572. IF 8,631 (2018).

Mishev K., Lu Q., Denoo B., Peurois F., Dejonghe W., Hullaert J., De Rycke R.M., Boeren S., Bretou M., De Munck S., Sharma I.S., Goodman K., Kalinowska K., Storme V., Nguyen L., Drozdzecki A., Martins S., Nerinckx W., Audenaert D., Vert G., Madder A., Otegui M.S., Isono E., Savvides S., Annaert W., de Vries S.C., Cherfils J., Winne J., Russinova E., 2018. Nonselective chemical inhibition of Sec7 domain-containing ARF GTPase exchange factors. The Plant Cell, 30(10): 2573-2593. IF 8,631 (2018).

Zhou J., Liu D., Wang P., Ma X., Lin W., Chen S., Mishev K., Lu D., Kumar R., Vanhoutte I., Meng X., He P., Russinova E., Shan L., 2018. Regulation of Arabidopsis brassinosteroid receptor BRI1 endocytosis and degradation by plant U-box PUB12/PUB13-mediated ubiquitination. Proc. Natl. Acad. Sci. U. S. A., 115(8): E1906-15. IF 9,580 (2018).

Dimitrova A.D., Georgiev O., Mishev K., Tzvetkov S., Ananiev E.D., Karagyozov L., 2016. Mapping of unmethylated sites in rDNA repeats in barley NOR deletion line. Journal of Plant Physiology, 205: 97-104. IF: 3,121 (2016).

Dejonghe W., Kuenen S., Mylle E., Vasileva M., Keech O., Viotti C., Swerts J., Fendrych M., Ortiz-Morea F.A., Mishev K., Delang S., Scholl S., Zarza X., Heilmann M., Kourelis J., Kasprowicz J., Nguyen le S.L., Drozdzecki A., Van Houtte I., Szatmári A.M., Majda M., Baisa G., Bednarek S.Y., Robert S., Audenaert D., Testerink C., Munnik T., Van Damme D., Heilmann I., Schumacher K., Winne J., Friml J., Verstreken P., Russinova E., 2016. Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification. Nature Communications, 7: 11710. IF: 12,124 (2016).

Betti C., Vanhoutte I., Coutuer S., De Rycke R.M., Mishev K., Vuylsteke M., Aesaert S., Rombaut D., Gallardo R., De Smet F., Xu J., Van Lijsebettens M., Van Breusegem F., Inzé D., Rousseau F., Schymkowitz J., Russinova E., 2016. Sequence-specific protein aggregation generates defined protein knockdowns in plants. Plant Physiology, 171: 773-787. IF: 6,456 (2016).

Dejonghe W., Mishev K., Russinova E., 2014. The brassinosteroid chemical toolbox. Current Opinion in Plant Biology, 22: 48-55. IF: 7,848 (2014).

Mishev K., Dejonghe W., Russinova E., 2013. Small molecules for dissecting endomembrane trafficking: a cross-systems view. Chemistry and Biology, 20: 475-486. IF: 6,586 (2013).

Ivanova A., Ananieva K., Mishev K., Ananiev E.D., 2012. Lipid composition in leaves and cotyledons of Cucurbita pepo L. (zucchini) during natural and induced senescence. Genetics and Plant Physiology, 2: 98-106.

Irani N.G., Di Rubbo S., Mylle E., Schneider-Pizon J., Van Den Begin J., Hnilikova J., Sisa M., Vilarrasa-Blasi J., Szatmari A.-M., Van Damme D., Mishev K., Codreanu M.-C., Kohout L., Strnad M., Cano-Delgado A.I., Friml J., Madder A., Russinova E., 2012. Fluorescent castasterone reveals BRI1 signaling from the plasma membrane. Nature Chemical Biology, 8: 583-589. IF: 12,948 (2012).

Ananieva K., Ananiev E.D., Doncheva S., Stefanov D., Mishev K., Kaminek M., Motyka V., Dobrev P., Malbeck J., 2011. Local induction of senescence by darkness in Cucurbita pepo (zucchini) cotyledons or the primary leaf induces opposite effects in the adjacent illuminated organ. Plant Growth Regulation, 65: 459-471. IF: 1,604 (2011).

Mishev K., Dimitrova A., Ananiev E.D., 2011. Darkness affects differentially the expression of plastid-encoded genes and delays the senescence-induced down-regulation of chloroplast transcription in cotyledons of Cucurbita pepo L. (zucchini). Zeitschrift für Naturforschung, 66c: 159-166. IF: 0,772 (2011).

Mishev K., Ananiev E.D., Humbeck K., 2011. Organ-specific effects of dark treatment on photosynthesis and the expression of photosynthesis-related genes. Biologia Plantarum, 55: 269-278. IF: 1,974 (2011).

Mishev K., Stefanov D., Ananieva K., Slavov C., Ananiev E.D., 2009. Different effects of dark treatment on pigment composition and photosystem I and II activities in intact cotyledons and primary leaves of Cucurbita pepo (zucchini). Plant Growth Regulation, 58: 61-71. IF: 1,530 (2009).

Ananieva K., Ananiev E.D., Mishev K., Georgieva K., Tzvetkova N., van Staden J., 2008. Changes in photosynthetic capacity and polypeptide patterns during natural senescence and rejuvenation of Cucurbita pepo L. (zucchini) cotyledons. Plant Growth Regulation, 54: 23-29. IF: 1,333 (2008).

Ananieva K., Ananiev E.D., Mishev K., Georgieva K., Malbeck J., Kaminek M., van Staden J., 2007. Methyl jasmonate is a more effective senescence-promoting factor in Cucurbita pepo (zucchini) cotyledons when compared with darkness at the early stage of senescence. Journal of Plant Physiology, 164: 1179-1187. IF: 2,239 (2007).

Mishev K., Denev I., Radeva G. and Ananiev E.D., 2006. RNA transcription in isolated chloroplasts during senescence and rejuvenation of intact cotyledons of Cucurbita pepo L. (zucchini). Comptes rendus de l’Academie Bulgare des Sciences, 59: 1287-1293.

Mishev K., Todorov I., and Ananiev E.D., 2005. Senescence and rejuvenation in intact cotyledons of Cucurbita pepo L. (zucchini). General and Applied Plant Physiology, 31: 15-27.

Doltchinkova V., Georgieva K., Traytcheva N., Slavov Ch., and Mishev K., 2004. Melittin-induced changes in thylakoid membranes: particle electrophoresis and light scattering study. Biophysical Chemistry, 109: 387-397. IF: 2,102 (2004).

Doltchinkova V., Slavov Ch., and Mishev K., 2004. Effect of bee venom melittin on biological membranes II. The effect of neutral pH on light scattering of thylakoid membranes in the presence of melittin. Annuaire de l’Universite de Sofia “St. Kliment Ohridski”, 96: 245-252.

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